CXCL13 biomarker for CSV inflammation including acute neuroborreliosis (UZ Leuven)

Purpose of the test

CXCL13 is a biomarker whose concentration increases in lumbar fluid in patients with central nervous system inflammation including acute neuroborreliosis.

Criteria for performing analyses under the reference activity

If sufficient sample is present when requesting a confirmation test for CSV, CXCL13 (ELISA) will also be performed. This test by itself is insufficient to diagnose neuroborreliosis and can only support the diagnosis in combination with other tests.

Instructions for samples

• Sample collection: Preferred volume is 0.5 ml (at least 250 microlitres is required).
• Storage conditions: samples can be kept refrigerated (2-8°C) for several days.

Instructions for transport

Send samples refrigerated (2-8°C) in a leakproof container.

Unacceptable requests

• Insufficient sample
• Excessive transport time (> a week) or under excessive heat (e.g. hot summer days) (see storage conditions above).
• Application form not completed in full. This is absolutely necessary. Extreme effort should be made to obtain minimum clinical data (registration is one of the objectives of the NRC).

Turn around time (and frequency of analysis)

Analysis is performed once a week.

Reporting of test results

Results will be sent via email and/or fax according to the requesting laboratory or physician’s wishes.