<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hubrechts,J.M.</style></author><author><style face="normal" font="default" size="100%">R. Vanhoof</style></author><author><style face="normal" font="default" size="100%">Daems,A.</style></author><author><style face="normal" font="default" size="100%">Butzler,J.P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Susceptibility of Gardnerella vaginalis to thiamphenicol: clinical experience with nonspecific vaginitis</style></title><secondary-title><style face="normal" font="default" size="100%">Sex Transm.Dis.</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">0</style></keyword><keyword><style  face="normal" font="default" size="100%">Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">ALL</style></keyword><keyword><style  face="normal" font="default" size="100%">an</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-Bacterial Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibiotic</style></keyword><keyword><style  face="normal" font="default" size="100%">antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">article</style></keyword><keyword><style  face="normal" font="default" size="100%">at</style></keyword><keyword><style  face="normal" font="default" size="100%">Case</style></keyword><keyword><style  face="normal" font="default" size="100%">Chloramphenicol</style></keyword><keyword><style  face="normal" font="default" size="100%">Clindamycin</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical</style></keyword><keyword><style  face="normal" font="default" size="100%">Comparative Study</style></keyword><keyword><style  face="normal" font="default" size="100%">drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">drug therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythromycin</style></keyword><keyword><style  face="normal" font="default" size="100%">Etiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Experience</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Follow up</style></keyword><keyword><style  face="normal" font="default" size="100%">FOLLOW-UP</style></keyword><keyword><style  face="normal" font="default" size="100%">Gardnerella vaginalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemophilus</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemophilus Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">im</style></keyword><keyword><style  face="normal" font="default" size="100%">Injections,Intramuscular</style></keyword><keyword><style  face="normal" font="default" size="100%">invitro</style></keyword><keyword><style  face="normal" font="default" size="100%">IS</style></keyword><keyword><style  face="normal" font="default" size="100%">journal</style></keyword><keyword><style  face="normal" font="default" size="100%">Metronidazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Microbial Sensitivity Tests</style></keyword><keyword><style  face="normal" font="default" size="100%">observed</style></keyword><keyword><style  face="normal" font="default" size="100%">pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Print</style></keyword><keyword><style  face="normal" font="default" size="100%">result</style></keyword><keyword><style  face="normal" font="default" size="100%">results</style></keyword><keyword><style  face="normal" font="default" size="100%">SB - IM</style></keyword><keyword><style  face="normal" font="default" size="100%">strain</style></keyword><keyword><style  face="normal" font="default" size="100%">study</style></keyword><keyword><style  face="normal" font="default" size="100%">Tetracycline</style></keyword><keyword><style  face="normal" font="default" size="100%">therapeutic use</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiamphenicol</style></keyword><keyword><style  face="normal" font="default" size="100%">treatment</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaginitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Volunteers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1984</style></year><pub-dates><date><style  face="normal" font="default" size="100%">0/10/1984</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">459</style></number><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">456 - 459</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">We compared the in-vitro activity of thiamphenicol against 100 strains of Gardnerella vaginalis with the activity of 11 other antimicrobial agents. The MICs for thiamphenicol ranged from 0.39 micrograms/ml to 6.25 micrograms/ml. The concentration at which 50% of strains were inhibited (MIC50) was 1.96 micrograms/ml, and the concentration at which 90% of strains were inhibited (MIC90) was 3.93 micrograms/ml. All strains were very susceptible to erythromycin, chloramphenicol, beta-lactam antibiotics, and clindamycin. Tetracycline and metronidazole were only moderately active. In an attempt to cure G. vaginalis-associated vaginitis with a single-dose treatment, we administered 2.25 g of thiamphenicol to 20 volunteers; 17 were clinically and bacteriologically cured. In two cases we observed that G. vaginalis was not eliminated immediately (i.e., at the first follow-up visit), but we saw a progressive disappearance of the strain without further treatment. In one case the treatment seemed to have failed but reinfection could not be ruled out. The results show that a single dose of thiamphenicol can cure G. vaginalis-associated vaginitis</style></abstract><issue><style face="normal" font="default" size="100%">4 Suppl</style></issue><custom1><style face="normal" font="default" size="100%">37316</style></custom1><section><style face="normal" font="default" size="100%">456</style></section></record></records></xml>