<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dillien, Philippe</style></author><author><style face="normal" font="default" size="100%">Susana Ferrao Santos</style></author><author><style face="normal" font="default" size="100%">van Pesch, Vincent</style></author><author><style face="normal" font="default" size="100%">Vanessa Suin</style></author><author><style face="normal" font="default" size="100%">Lamoral, Sophie</style></author><author><style face="normal" font="default" size="100%">Hantson, Philippe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">New-Onset Refractory Status Epilepticus: More Investigations, More Questions.</style></title><secondary-title><style face="normal" font="default" size="100%">Case Rep Neurol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Case Rep Neurol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cryptogenic origin</style></keyword><keyword><style  face="normal" font="default" size="100%">Japanese encephalitis virus</style></keyword><keyword><style  face="normal" font="default" size="100%">New-onset refractory status epilepticus</style></keyword><keyword><style  face="normal" font="default" size="100%">Seronegative limbic encephalitis</style></keyword><keyword><style  face="normal" font="default" size="100%">SMC3 gene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016 May-Aug</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">133</style></number><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">127-33</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A 27-year-old previously healthy woman was admitted to the hospital with recurrent seizures. Status epilepticus developed that became refractory to third-line therapy with propofol and barbiturates. The patient had a very extensive diagnostic workup including autoimmune, viral and genetic investigations. A tentative immune therapy was proposed with high doses of steroids and plasma exchanges. Our patient had an inherited heterozygous single nucleotide variant in the sequence c.1280A&amp;gt;G [p.Lys427Arg] of the SMC3 gene that was insufficient to explain the seizures. Surprisingly, IgM antibodies against Japanese encephalitis virus were positive on the serum drawn 11 days after symptom onset, as detected by ELISA and the immunofluorescence antibody (IFA) technique. IgG antibodies were also positive using the IFA technique, but not with ELISA. The same investigations as well as the detection of the viral genome by the q-RT-PCR technique were negative on cerebrospinal fluid. Despite the suspicion of a viral infection, we concluded that our patient had a new-onset refractory status epilepticus of cryptogenic origin. Termination of the status epilepticus was obtained after 47 days, with a possible benefit from the introduction of ketamine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/27462243?dopt=Abstract</style></custom1><section><style face="normal" font="default" size="100%">127</style></section></record></records></xml>