<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Michael Biggel</style></author><author><style face="normal" font="default" size="100%">Stefan Heytens</style></author><author><style face="normal" font="default" size="100%">Katrien Latour</style></author><author><style face="normal" font="default" size="100%">Bruyndonckx, Robin</style></author><author><style face="normal" font="default" size="100%">Goossens, Herman</style></author><author><style face="normal" font="default" size="100%">Pieter Moons</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Asymptomatic bacteriuria in older adults: the most fragile women are prone to long-term colonization</style></title><secondary-title><style face="normal" font="default" size="100%">BMC Geriatrics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asymptomatic bacteriuria</style></keyword><keyword><style  face="normal" font="default" size="100%">older adults</style></keyword><keyword><style  face="normal" font="default" size="100%">urinary tract infection</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan-12-2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">19</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Background: The diagnosis of urinary tract infections (UTIs) in institutionalized older adults is often based on vague&lt;/p&gt;

&lt;p&gt;symptoms and a positive culture. The high prevalence of asymptomatic bacteriuria (ABU), which cannot be easily&lt;/p&gt;

&lt;p&gt;discriminated from an acute infection in this population, is frequently neglected, leading to a vast over-prescription&lt;/p&gt;

&lt;p&gt;of antibiotics. This study aimed to identify subpopulations predisposed to transient or long-term ABU.&lt;/p&gt;

&lt;p&gt;Methods: Residents in a long-term care facility were screened for ABU. Mid-stream urine samples were collected&lt;/p&gt;

&lt;p&gt;during two sampling rounds, separated by 10 weeks, each consisting of an initial and a confirmative follow-up&lt;/p&gt;

&lt;p&gt;sample.&lt;/p&gt;

&lt;p&gt;Results: ABU occurred in approximately 40% of the participants and was mostly caused by Escherichia coli. Long-term&lt;/p&gt;

&lt;p&gt;ABU (&amp;gt; 3 months) was found in 30% of the subjects. The frailest women with urinary incontinence and dementia had&lt;/p&gt;

&lt;p&gt;drastically increased rates of ABU and especially long-term ABU. ABU was best predicted by a scale describing the&lt;/p&gt;

&lt;p&gt;functional independence of older adults.&lt;/p&gt;

&lt;p&gt;Conclusions: Institutionalized women with incontinence have ABU prevalence rates of about 80% and are often&lt;/p&gt;

&lt;p&gt;persistent carriers. Such prevalence rates should be considered in clinical decision making as they devalue the meaning&lt;/p&gt;

&lt;p&gt;of a positive urine culture as a criterion to diagnose UTIs. Diagnostic strategies are urgently needed to avoid antibiotic&lt;/p&gt;

&lt;p&gt;overuse and to identify patients at risk to develop upper UTI.&lt;/p&gt;
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