<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rónán O'Caoimh</style></author><author><style face="normal" font="default" size="100%">Lucia Galluzzo</style></author><author><style face="normal" font="default" size="100%">Ángel Rodríguez-Laso</style></author><author><style face="normal" font="default" size="100%">Johan Van der Heyden</style></author><author><style face="normal" font="default" size="100%">Anette Ranhoff Hylen</style></author><author><style face="normal" font="default" size="100%">Laure Carcaillon-Bentata</style></author><author><style face="normal" font="default" size="100%">Nathalie Beltzer</style></author><author><style face="normal" font="default" size="100%">Siobhán Kennelly</style></author><author><style face="normal" font="default" size="100%">Aaron Liew</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">Work Package 5 of the Joint Action ADVANTAGE</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE.</style></title><secondary-title><style face="normal" font="default" size="100%">Ann Ist Super Sanita</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged, 80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Progression</style></keyword><keyword><style  face="normal" font="default" size="100%">Europe</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Frail Elderly</style></keyword><keyword><style  face="normal" font="default" size="100%">frailty</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Longitudinal Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">middle aged</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018 Jul-Sep</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">54</style></volume><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;INTRODUCTION: &lt;/b&gt;Frailty is a dynamic syndrome and may be reversible. Despite this, little is known about trajectories or transitions between different stages of frailty.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;A systematic review was conducted, selecting studies reporting frailty trajectories or transition states for adults in any settings in European ADVANTAGE Joint Action Member States.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Only three papers were included. Data were from longitudinal community-based cohorts in the United Kingdom, Netherlands and Italy. The English study investigated the effect of physical activity on the progression of frailty over a 10-year period. Two presented data on the proportion of participants experiencing at least one frailty transition over time (32.6% in the Italian sample aged ≥ 65 years followed for 4.4 years; 34.3% in the Dutch sample aged 65-75 years, followed for 2 years).&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;Data on frailty trajectories and transition states were limited and heterogeneous. Well-designed prospective studies and harmonized approaches to data collection are now needed.&lt;/p&gt;
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