<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Celine Meerpoel</style></author><author><style face="normal" font="default" size="100%">Arnau Vidal</style></author><author><style face="normal" font="default" size="100%">Bart Huybrechts</style></author><author><style face="normal" font="default" size="100%">Emmanuel Tangni</style></author><author><style face="normal" font="default" size="100%">S. De Saeger</style></author><author><style face="normal" font="default" size="100%">Croubels, Siska</style></author><author><style face="normal" font="default" size="100%">Devreese, Mathias</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens</style></title><secondary-title><style face="normal" font="default" size="100%">Food and Chemical Toxicology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">jul 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">141</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A comprehensive toxicokinetic analysis of citrinin (CIT) revealed interspecies differences for all toxicokinetic parameters and in absolute oral bioavailability. Oral bioavailability for CIT was complete for broilers (113-131%), while ranging from 37 to 44% in pigs. CIT was more rapidly absorbed in pigs (Tmax&amp;nbsp;= 0.92 h) compared to broiler chickens (Tmax&amp;nbsp;= 7.33 h). The elimination of CIT was slower in pigs (T1/2el&amp;nbsp;= 26.81 h after intravenous (IV) administration) compared to chickens (T1/2el&amp;nbsp;= 1.97 h after IV administration), due to the striking difference in clearance (Cliv=9.87 mL/h/kg for pigs versus Cliv&amp;nbsp;= 863.09 mL/h/kg for broilers). Also, the volume of distribution differed significantly between pigs (Vd = 0.30 L/kg after IV administration) and chickens (Vd = 2.46 L/kg after IV administration). However, plasma protein binding did not differ statistically significant (91-98%). It is imperative to further investigate biotransformation and elimination pathways in different species, including humans.&lt;/p&gt;
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