<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Birgit Mertens</style></author><author><style face="normal" font="default" size="100%">Annelies Van Heyst</style></author><author><style face="normal" font="default" size="100%">Heidi Demaegdt</style></author><author><style face="normal" font="default" size="100%">Imke Boonen</style></author><author><style face="normal" font="default" size="100%">Kathy Van Den Houwe</style></author><author><style face="normal" font="default" size="100%">Séverine Goscinny</style></author><author><style face="normal" font="default" size="100%">Elskens, Marc</style></author><author><style face="normal" font="default" size="100%">Els Van Hoeck</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of hazards and risks associated with dietary exposure to mineral oil for the Belgian population</style></title><secondary-title><style face="normal" font="default" size="100%">Food and Chemical Toxicology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CALUX® bioassay</style></keyword><keyword><style  face="normal" font="default" size="100%">endocrine activity</style></keyword><keyword><style  face="normal" font="default" size="100%">genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Mineral oil aromatic hydrocarbons</style></keyword><keyword><style  face="normal" font="default" size="100%">Mineral oil saturated hydrocarbons</style></keyword><keyword><style  face="normal" font="default" size="100%">Modified Ames test</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan-03-2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">149</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Recently collected dietary exposure data on mineral oil saturated (MOSH) and aromatic (MOAH) hydrocarbons were used to evaluate the risks associated with exposure to mineral oil through food for the Belgian population. For MOSH, the no observed adverse effect level (NOAEL) value of 19&amp;nbsp;mg&amp;nbsp;kg−1&amp;nbsp;bw day−1&amp;nbsp;based on the hepatic inflammation-associated granulomas found in a 90-day oral study in F-344 rats was used as point of departure (PoD). Due to existing toxicological uncertainties, the margin of exposure (MOE) approach was applied. In all investigated scenarios, the MOE values were well above 100, indicating that there is no direct health concern related to MOSH exposure for the Belgian population. Nevertheless, more appropriate risk assessment approaches for MOSH based on adequate PoD are needed. For dietary exposure to MOAH, which are potentially genotoxic and carcinogenic, no MOE values could be calculated due to the lack of adequate dose-response carcinogenicity data. In two investigated worst-case scenarios, a health concern related to MOAH exposure could not be excluded, highlighting that more data are needed to perform an adequate risk assessment. The possibility to use&amp;nbsp;in vitro&amp;nbsp;bioassays to collect such additional toxicological information for MOAH present in food samples was also investigated.&lt;/p&gt;
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