<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Steven Van Vooren</style></author><author><style face="normal" font="default" size="100%">James Grayson</style></author><author><style face="normal" font="default" size="100%">Van Ranst, Marc</style></author><author><style face="normal" font="default" size="100%">Elisabeth Dequeker</style></author><author><style face="normal" font="default" size="100%">Lies Laenen</style></author><author><style face="normal" font="default" size="100%">Reile Janssen</style></author><author><style face="normal" font="default" size="100%">Gillet, Laurent</style></author><author><style face="normal" font="default" size="100%">Bureau, Fabrice</style></author><author><style face="normal" font="default" size="100%">Wouter Coppieters</style></author><author><style face="normal" font="default" size="100%">Nathalie Devos</style></author><author><style face="normal" font="default" size="100%">Benjamin Hengchen</style></author><author><style face="normal" font="default" size="100%">P Wattiau</style></author><author><style face="normal" font="default" size="100%">Sibylle Méhauden</style></author><author><style face="normal" font="default" size="100%">Yvan Verlinden</style></author><author><style face="normal" font="default" size="100%">Kurt Van Baelen</style></author><author><style face="normal" font="default" size="100%">Theresa Pattery</style></author><author><style face="normal" font="default" size="100%">Jean-Pierre Valentin</style></author><author><style face="normal" font="default" size="100%">Kris Janssen</style></author><author><style face="normal" font="default" size="100%">Martine Geraerts</style></author><author><style face="normal" font="default" size="100%">John Smeraglia</style></author><author><style face="normal" font="default" size="100%">Jan Hellemans</style></author><author><style face="normal" font="default" size="100%">Pieter Wytynck</style></author><author><style face="normal" font="default" size="100%">Pieter Mestdagh</style></author><author><style face="normal" font="default" size="100%">Nienke Besbrugge</style></author><author><style face="normal" font="default" size="100%">René Höfer</style></author><author><style face="normal" font="default" size="100%">Friedel Nollet</style></author><author><style face="normal" font="default" size="100%">Vandesompele, Jo</style></author><author><style face="normal" font="default" size="100%">Pieter De Smet</style></author><author><style face="normal" font="default" size="100%">John Lebon</style></author><author><style face="normal" font="default" size="100%">Emmanuel Vandewynckele</style></author><author><style face="normal" font="default" size="100%">Steven Verstrepen</style></author><author><style face="normal" font="default" size="100%">Wouter Uten</style></author><author><style face="normal" font="default" size="100%">Arnaud Capron</style></author><author><style face="normal" font="default" size="100%">Hugues Malonne</style></author><author><style face="normal" font="default" size="100%">J Poels</style></author><author><style face="normal" font="default" size="100%">Emmanuel André</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reliable and Scalable SARS-CoV-2 qPCR Testing at a High Sample Throughput: Lessons Learned from the Belgian Initiative.</style></title><secondary-title><style face="normal" font="default" size="100%">Life (Basel)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Jan 21</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We present our approach to rapidly establishing a standardized, multi-site, nation-wide COVID-19 screening program in Belgium. Under auspices of a federal government Task Force responsible for upscaling the country's testing capacity, we were able to set up a national testing initiative with readily available resources, putting in place a robust, validated, high-throughput, and decentralized qPCR molecular testing platform with embedded proficiency testing. We demonstrate how during an acute scarcity of equipment, kits, reagents, personnel, protective equipment, and sterile plastic supplies, we introduced an approach to rapidly build a reliable, validated, high-volume, high-confidence workflow based on heterogeneous instrumentation and diverse assays, assay components, and protocols. The workflow was set up with continuous quality control monitoring, tied together through a clinical-grade information management platform for automated data analysis, real-time result reporting across different participating sites, qc monitoring, and making result data available to the requesting physician and the patient. In this overview, we address challenges in optimizing high-throughput cross-laboratory workflows with minimal manual intervention through software, instrument and assay validation and standardization, and a process for harmonized result reporting and nation-level infection statistics monitoring across the disparate testing methodologies and workflows, necessitated by a rapid scale-up as a response to the pandemic.&lt;/p&gt;
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