<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sivakumar Murugadoss</style></author><author><style face="normal" font="default" size="100%">Ivana Vinković Vrček</style></author><author><style face="normal" font="default" size="100%">Alexandra Schaffert</style></author><author><style face="normal" font="default" size="100%">Martin Paparella</style></author><author><style face="normal" font="default" size="100%">Barbara Pem</style></author><author><style face="normal" font="default" size="100%">Anita Sosnowska</style></author><author><style face="normal" font="default" size="100%">Maciej Stępnik</style></author><author><style face="normal" font="default" size="100%">Marvin Martens</style></author><author><style face="normal" font="default" size="100%">Egon L Willighagen</style></author><author><style face="normal" font="default" size="100%">Tomasz Puzyn</style></author><author><style face="normal" font="default" size="100%">Mihaela Roxana Cimpan</style></author><author><style face="normal" font="default" size="100%">Frauke Lemaire</style></author><author><style face="normal" font="default" size="100%">Birgit Mertens</style></author><author><style face="normal" font="default" size="100%">Maria Dusinska</style></author><author><style face="normal" font="default" size="100%">Valerie Fessard</style></author><author><style face="normal" font="default" size="100%">Peter H Hoet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals.</style></title><secondary-title><style face="normal" font="default" size="100%">ALTEX</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Aug 08</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The Adverse Outcome Pathway (AOP) framework plays a crucial role in the paradigm shift of toxicity testing towards the development and use of new approach methodologies. AOPs developed for chemicals are in theory applicable to nanomaterials (NMs). However, only subtle efforts have been made to integrate information on NM-induced toxicity into existing AOPs. In a previous study, we identified AOPs in the AOP-Wiki associated with the molecular initiating events (MIEs) and key events (KEs) reported for NMs in scientific literature. In a next step, we analyzed these AOPs and found that mitochondrial toxicity plays a significant role in several of them at the molecular and cellular levels. In this study, we aimed to generate hypothesis-based AOPs related to NM-induced mitochondrial toxicity. This was achieved by integrating science-based information collected on NM-induced mitochondrial toxicity into all existing AOPs in the AOP-Wiki, which already includes mitochondrial toxicity as a MIE/KE. The results showed that several AOPs in the AOP-Wiki related to the lung, liver, cardiovascular and nervous system, with extensively defined KEs and key event relationships (KERs), could be utilized to develop AOPs that are relevant for NMs. Our results also indicate that the majority of the studies included in our literature review were of poor quality, particularly in reporting NM physico-chemical characteristics, and NM-relevant mitochondrial MIEs were scarcely reported. This study highlights the potential role of NM-induced mitochondrial toxicity in human-relevant adverse outcomes and identifies useful AOPs in the AOP-Wiki for the development AOPs that are relevant for NMs.&lt;/p&gt;
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