<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laura Downham</style></author><author><style face="normal" font="default" size="100%">Iman Jaafar</style></author><author><style face="normal" font="default" size="100%">Mary Luz Rol</style></author><author><style face="normal" font="default" size="100%">Victoria N Nyaga</style></author><author><style face="normal" font="default" size="100%">Joan Valls</style></author><author><style face="normal" font="default" size="100%">Armando Baena</style></author><author><style face="normal" font="default" size="100%">Zhang, Li</style></author><author><style face="normal" font="default" size="100%">Marc J Gunter</style></author><author><style face="normal" font="default" size="100%">M. Arbyn</style></author><author><style face="normal" font="default" size="100%">Maribel Almonte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Accuracy of HPV E6/E7 oncoprotein tests to detect high-grade cervical lesions: a systematic literature review and meta-analysis.</style></title><secondary-title><style face="normal" font="default" size="100%">Br J Cancer</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cervical cardiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical lesions</style></keyword><keyword><style  face="normal" font="default" size="100%">HPV</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Nov 16</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;&lt;strong style=&quot;color:#69aa41;&quot;&gt;BACKGROUND:&lt;/strong&gt; &lt;/b&gt;&lt;br&gt;
Cervical carcinogenesis is mediated by the HPV-E6 and E7 oncoproteins, considered as biomarkers usable in managing screen-positive women.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;&lt;strong style=&quot;color:#69aa41;&quot;&gt;METHODS:&lt;/strong&gt; &lt;/b&gt;&lt;br&gt;
We conducted a systematic review and meta-analysis assessing the accuracy of HPV-E6/E7-oncoprotein tests to detect underlying cervical-precancer and cancer. We included studies reporting data on oncoprotein test accuracy detecting cervical intraepithelial neoplasia grade 3 or worse. Random effects logistic regression models were applied for pooling absolute and relative accuracy.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;&lt;strong style=&quot;color:#69aa41;&quot;&gt;RESULTS:&lt;/strong&gt; &lt;/b&gt;&lt;br&gt;
Twenty-two studies were included. Sensitivity and specificity estimates ranged from 54.2% (95%CI: 45.2-63.0) to 69.5% (95%CI:60.8-76.9) and from 82.8% (95%CI: 50.4-95.8) to 99.1 (95%CI: 98.8-99.3), respectively in the population irrespective of HPV status. Higher sensitivity estimates ranging from 60.8% (95%CI: 49.6-70.9) to 75.5% (95%CI: 71.7-78.9) but lower specificity estimates ranging from 83.7% (95%CI: 76.1-89.3) to 92.1% (95%CI: 88.5-94.6) were observed in studies enrolling high-risk-HPV-positive women. Studies recruiting only HIV-positive women showed a pooled sensitivity of 46.9% (95%CI: 30.6-63.9) with a specificity of 98.0% (95%CI: 96.8-98.7).&lt;/p&gt;

&lt;p&gt;&lt;strong style=&quot;color:#69aa41;&quot;&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;&lt;/strong&gt;&lt;br&gt;
The high specificity of oncoprotein tests supports its use for triaging HPV-positive women. However, oncoprotein-negative women would not be recommended to undertake routine screening, requiring further follow-up. Large-scale and longitudinal studies are needed to further investigate the role of E6/E7-oncoprotein detection in predicting the risk of developing cervical pre-cancer and cancer.&lt;/p&gt;
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