<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Semenchuk, Julie</style></author><author><style face="normal" font="default" size="100%">Naito, Yumi</style></author><author><style face="normal" font="default" size="100%">Charman, Susan C</style></author><author><style face="normal" font="default" size="100%">Carr, Siobhán B</style></author><author><style face="normal" font="default" size="100%">Cheng, Stephanie Y</style></author><author><style face="normal" font="default" size="100%">Marshall, Bruce C</style></author><author><style face="normal" font="default" size="100%">Faro, Albert</style></author><author><style face="normal" font="default" size="100%">Elbert, Alexander</style></author><author><style face="normal" font="default" size="100%">Gutierrez, Hector H</style></author><author><style face="normal" font="default" size="100%">Goss, Christopher H</style></author><author><style face="normal" font="default" size="100%">Karadag, Bulent</style></author><author><style face="normal" font="default" size="100%">Burgel, Pierre-Régis</style></author><author><style face="normal" font="default" size="100%">Colombo, Carla</style></author><author><style face="normal" font="default" size="100%">Salvatore, Marco</style></author><author><style face="normal" font="default" size="100%">Padoan, Rita</style></author><author><style face="normal" font="default" size="100%">Daneau, Géraldine</style></author><author><style face="normal" font="default" size="100%">Harutyunyan, Satenik</style></author><author><style face="normal" font="default" size="100%">Kashirskaya, Nataliya</style></author><author><style face="normal" font="default" size="100%">Kirwan, Laura</style></author><author><style face="normal" font="default" size="100%">Middleton, Peter G</style></author><author><style face="normal" font="default" size="100%">Ruseckaite, Rasa</style></author><author><style face="normal" font="default" size="100%">de Monestrol, Isabelle</style></author><author><style face="normal" font="default" size="100%">Naehrlich, Lutz</style></author><author><style face="normal" font="default" size="100%">Mondejar-Lopez, Pedro</style></author><author><style face="normal" font="default" size="100%">Jung, Andreas</style></author><author><style face="normal" font="default" size="100%">van Rens, Jacqui</style></author><author><style face="normal" font="default" size="100%">Bakkeheim, Egil</style></author><author><style face="normal" font="default" size="100%">Orenti, Annalisa</style></author><author><style face="normal" font="default" size="100%">Zomer-van Ommen, Domenique</style></author><author><style face="normal" font="default" size="100%">da Silva-Filho, Luiz Vicente Rf</style></author><author><style face="normal" font="default" size="100%">Fernandes, Flavia Fonseca</style></author><author><style face="normal" font="default" size="100%">Zampoli, Marco</style></author><author><style face="normal" font="default" size="100%">Stephenson, Anne L</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">Global CF Registry Collaboration</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study.</style></title><secondary-title><style face="normal" font="default" size="100%">J Cyst Fibros</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Cystic Fibrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced Expiratory Volume</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">nutritional status</style></keyword><keyword><style  face="normal" font="default" size="100%">Respiratory Function Tests</style></keyword><keyword><style  face="normal" font="default" size="100%">Retrospective Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024 Sep</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">23</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).&lt;/p&gt;

&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.&lt;/p&gt;
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