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Increased vancomycin susceptibility in mycobacteria: a new approach to identify synergistic activity against multi-drug resistant mycobacteria36969

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1128/AAC.04856-14 [1]

Authors

Karine Soetaert [2]; Rens,C. [3]; Wang,X.M. [4]; J. De Bruyn [5]; M.A. Lanéelle [6]; Laval,F. [7]; Lemassu,A. [8]; M. Daffe [9]; Bifani,P. [10]; Fontaine,V. [11]; P. Lefevre [12]

Keywords

  1. a [13]
  2. Activity [14]
  3. Agent [15]
  4. Agents [16]
  5. Antibiotic [17]
  6. antibiotics [18]
  7. approach [19]
  8. approaches [20]
  9. article [21]
  10. BCG [22]
  11. Belgium [23]
  12. Biology [24]
  13. Brussels [25]
  14. Bruxelles [26]
  15. Clinical [27]
  16. comparing [28]
  17. de [29]
  18. disease [30]
  19. Diseases [31]
  20. DRUG [32]
  21. electronic [33]
  22. France [34]
  23. health [35]
  24. Hygiene [36]
  25. identify [37]
  26. INFECTION [38]
  27. Infectious [39]
  28. Infectious diseases [40]
  29. Institute [41]
  30. IS [42]
  31. journal [43]
  32. Lipids [44]
  33. M [45]
  34. microbiology [46]
  35. Mycobacterium [47]
  36. Mycobacterium tuberculosis [48]
  37. observed [49]
  38. pharmacology [50]
  39. public [51]
  40. public health [52]
  41. Public-health [53]
  42. strain [54]
  43. Strategies [55]
  44. Strategy [56]
  45. study [57]
  46. Tuberculosis [58]
  47. Universities [59]
  48. university [60]
  49. Vancomycin [61]
  50. WIV-ISP [62]

Abstract:

Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing M. bovis BCG and M. tuberculosis mutants, lacking phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids, with wild-type strains, we observed that glycopeptides strongly inhibited PDIM deprived mycobacteria. Vancomycin together with a drug targeting lipids synthesis inhibited multidrug-resistant (MDR) and extensively-drug resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential anti-TB agents and might provide a new antimycobacterial drug-screening s…
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Source URL:https://sciensano.be/en/biblio/increased-vancomycin-susceptibility-mycobacteria-a-new-approach-identify-synergistic-activity

Links
[1] http://dx.doi.org/10.1128/AAC.04856-14 [2] https://sciensano.be/en/people/karine-soetaert/biblio [3] https://sciensano.be/en/biblio?f%5Bauthor%5D=27648&f%5Bsearch%5D=Rens%2CC. [4] https://sciensano.be/en/biblio?f%5Bauthor%5D=25320&f%5Bsearch%5D=Wang%2CX.M. [5] https://sciensano.be/en/biblio?f%5Bauthor%5D=21429&f%5Bsearch%5D=J.%20De%20Bruyn [6] https://sciensano.be/en/biblio?f%5Bauthor%5D=27651&f%5Bsearch%5D=M.A.%20Lan%C3%A9elle [7] https://sciensano.be/en/biblio?f%5Bauthor%5D=27654&f%5Bsearch%5D=Laval%2CF. [8] https://sciensano.be/en/biblio?f%5Bauthor%5D=27657&f%5Bsearch%5D=Lemassu%2CA. [9] https://sciensano.be/en/biblio?f%5Bauthor%5D=23892&f%5Bsearch%5D=M.%20Daffe [10] https://sciensano.be/en/biblio?f%5Bauthor%5D=1215&f%5Bsearch%5D=Bifani%2CP. [11] https://sciensano.be/en/biblio?f%5Bauthor%5D=27660&f%5Bsearch%5D=Fontaine%2CV. [12] https://sciensano.be/en/biblio?f%5Bauthor%5D=25311&f%5Bsearch%5D=P.%20Lefevre [13] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1029&f%5Bsearch%5D=a [14] https://sciensano.be/en/biblio?f%5Bkeyword%5D=945&f%5Bsearch%5D=Activity [15] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1257&f%5Bsearch%5D=Agent [16] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2352&f%5Bsearch%5D=Agents [17] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2028&f%5Bsearch%5D=Antibiotic [18] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2031&f%5Bsearch%5D=antibiotics [19] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1776&f%5Bsearch%5D=approach [20] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1779&f%5Bsearch%5D=approaches [21] https://sciensano.be/en/biblio?f%5Bkeyword%5D=618&f%5Bsearch%5D=article [22] https://sciensano.be/en/biblio?f%5Bkeyword%5D=17670&f%5Bsearch%5D=BCG [23] https://sciensano.be/en/biblio?f%5Bkeyword%5D=444&f%5Bsearch%5D=Belgium [24] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1047&f%5Bsearch%5D=Biology [25] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1467&f%5Bsearch%5D=Brussels [26] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2583&f%5Bsearch%5D=Bruxelles [27] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1995&f%5Bsearch%5D=Clinical [28] https://sciensano.be/en/biblio?f%5Bkeyword%5D=4098&f%5Bsearch%5D=comparing [29] https://sciensano.be/en/biblio?f%5Bkeyword%5D=519&f%5Bsearch%5D=de [30] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1266&f%5Bsearch%5D=disease [31] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1341&f%5Bsearch%5D=Diseases [32] https://sciensano.be/en/biblio?f%5Bkeyword%5D=3015&f%5Bsearch%5D=DRUG [33] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2169&f%5Bsearch%5D=electronic [34] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2592&f%5Bsearch%5D=France [35] https://sciensano.be/en/biblio?f%5Bkeyword%5D=888&f%5Bsearch%5D=health [36] https://sciensano.be/en/biblio?f%5Bkeyword%5D=4368&f%5Bsearch%5D=Hygiene [37] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1434&f%5Bsearch%5D=identify [38] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1578&f%5Bsearch%5D=INFECTION [39] https://sciensano.be/en/biblio?f%5Bkeyword%5D=3117&f%5Bsearch%5D=Infectious [40] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1353&f%5Bsearch%5D=Infectious%20diseases [41] https://sciensano.be/en/biblio?f%5Bkeyword%5D=954&f%5Bsearch%5D=Institute [42] https://sciensano.be/en/biblio?f%5Bkeyword%5D=525&f%5Bsearch%5D=IS [43] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2190&f%5Bsearch%5D=journal [44] https://sciensano.be/en/biblio?f%5Bkeyword%5D=20367&f%5Bsearch%5D=Lipids [45] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2814&f%5Bsearch%5D=M [46] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2196&f%5Bsearch%5D=microbiology [47] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2697&f%5Bsearch%5D=Mycobacterium [48] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2769&f%5Bsearch%5D=Mycobacterium%20tuberculosis [49] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1869&f%5Bsearch%5D=observed [50] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2376&f%5Bsearch%5D=pharmacology [51] https://sciensano.be/en/biblio?f%5Bkeyword%5D=834&f%5Bsearch%5D=public [52] https://sciensano.be/en/biblio?f%5Bkeyword%5D=420&f%5Bsearch%5D=public%20health [53] https://sciensano.be/en/biblio?f%5Bkeyword%5D=975&f%5Bsearch%5D=Public-health [54] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2490&f%5Bsearch%5D=strain [55] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1446&f%5Bsearch%5D=Strategies [56] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1449&f%5Bsearch%5D=Strategy [57] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1191&f%5Bsearch%5D=study [58] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2712&f%5Bsearch%5D=Tuberculosis [59] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2343&f%5Bsearch%5D=Universities [60] https://sciensano.be/en/biblio?f%5Bkeyword%5D=2346&f%5Bsearch%5D=university [61] https://sciensano.be/en/biblio?f%5Bkeyword%5D=21564&f%5Bsearch%5D=Vancomycin [62] https://sciensano.be/en/biblio?f%5Bkeyword%5D=1056&f%5Bsearch%5D=WIV-ISP