<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ates, Gamze</style></author><author><style face="normal" font="default" size="100%">Favyts, Dorien</style></author><author><style face="normal" font="default" size="100%">Hendriks, Giel</style></author><author><style face="normal" font="default" size="100%">Derr, Remco</style></author><author><style face="normal" font="default" size="100%">Birgit Mertens</style></author><author><style face="normal" font="default" size="100%">Luc Verschaeve</style></author><author><style face="normal" font="default" size="100%">Rogiers, Vera</style></author><author><style face="normal" font="default" size="100%">Tatyana Yordanova Doktorova</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Vitotox and ToxTracker assays: a two-test combination for quick and reliable assessment of genotoxic hazards</style></title><secondary-title><style face="normal" font="default" size="100%">Mutation research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">an</style></keyword><keyword><style  face="normal" font="default" size="100%">analysi</style></keyword><keyword><style  face="normal" font="default" size="100%">analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">approach</style></keyword><keyword><style  face="normal" font="default" size="100%">AS</style></keyword><keyword><style  face="normal" font="default" size="100%">assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">chemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Combination</style></keyword><keyword><style  face="normal" font="default" size="100%">cosmetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Development</style></keyword><keyword><style  face="normal" font="default" size="100%">Europe</style></keyword><keyword><style  face="normal" font="default" size="100%">Follow up</style></keyword><keyword><style  face="normal" font="default" size="100%">FOLLOW-UP</style></keyword><keyword><style  face="normal" font="default" size="100%">genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">hazard</style></keyword><keyword><style  face="normal" font="default" size="100%">health</style></keyword><keyword><style  face="normal" font="default" size="100%">Human</style></keyword><keyword><style  face="normal" font="default" size="100%">human health</style></keyword><keyword><style  face="normal" font="default" size="100%">INFORMATION</style></keyword><keyword><style  face="normal" font="default" size="100%">IS</style></keyword><keyword><style  face="normal" font="default" size="100%">Less</style></keyword><keyword><style  face="normal" font="default" size="100%">Paper</style></keyword><keyword><style  face="normal" font="default" size="100%">performance</style></keyword><keyword><style  face="normal" font="default" size="100%">result</style></keyword><keyword><style  face="normal" font="default" size="100%">results</style></keyword><keyword><style  face="normal" font="default" size="100%">SENSITIVITY</style></keyword><keyword><style  face="normal" font="default" size="100%">Test</style></keyword><keyword><style  face="normal" font="default" size="100%">variety</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitotox</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">1/11/2016</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">21</style></number><volume><style face="normal" font="default" size="100%">810</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;To ensure human health, it is essential to characterize the genotoxic potential of new chemical entities such as pharmaceutical and cosmetic substances. In a first tier a battery of regulatory accepted in vitro tests is recommended. These tests have a relatively high sensitivity, but a low specificity. Furthermore, they are time-consuming, laborious and require large quantities of the individual chemicals. New assays overcoming these drawbacks are under development, the majority of them being reporter-based assays. In this paper we investigate the performance of two in vitro reporter-based assays, namely the Vitotox and the ToxTracker. A set of reference compounds were selected to cover not only different mechanisms of genotoxic action, but also a variety of applicability domains (e.g. pharmaceutical and cosmetic ingredients). Results show that both assays can be valuable tools in genotoxicity hazard assessment, especially when combined in a test battery. An interesting property of both assays for drug-development is the possibility of time-efficient analysis of a large amount of drug-candidates while using small quantities and high throughput (automatized) technologies. Furthermore, the tests are less laborious. For the cosmetic industry, the generated information can be added in a weight-of-evidence approach to derisk false positive results as in vivo follow-up testing is no longer allowed in Europe.&lt;/p&gt;
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