<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yana Debie</style></author><author><style face="normal" font="default" size="100%">Timon Vandamme</style></author><author><style face="normal" font="default" size="100%">Debbie Le Blon</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Jonas R M Van Audenaerde</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Lieselot Croes</style></author><author><style face="normal" font="default" size="100%">Christof Vulsteke</style></author></tertiary-authors><subsidiary-authors><author><style face="normal" font="default" size="100%">Laure-Anne Teuwen</style></author><author><style face="normal" font="default" size="100%">Lise Verbruggen</style></author><author><style face="normal" font="default" size="100%">Greetje Vanhoutte</style></author><author><style face="normal" font="default" size="100%">Elly Marcq</style></author><author><style face="normal" font="default" size="100%">Lisa Verheggen</style></author><author><style face="normal" font="default" size="100%">Bart Peeters</style></author><author><style face="normal" font="default" size="100%">Maria Goossens</style></author><author><style face="normal" font="default" size="100%">Pieter Pannus</style></author><author><style face="normal" font="default" size="100%">Ariën, Kevin K</style></author><author><style face="normal" font="default" size="100%">Sébastien Anguille</style></author><author><style face="normal" font="default" size="100%">Annelies Janssens</style></author><author><style face="normal" font="default" size="100%">Hans Prenen</style></author><author><style face="normal" font="default" size="100%">Evelien L J Smits</style></author><author><style face="normal" font="default" size="100%">Eva Lion</style></author><author><style face="normal" font="default" size="100%">Peeters, Marc</style></author><author><style face="normal" font="default" size="100%">Peter A van Dam</style></author></subsidiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Humoral and cellular immune responses against SARS-CoV-2 after third dose BNT162b2 following double-dose vaccination with BNT162b2 versus ChAdOx1 in cancer patients.</style></title><secondary-title><style face="normal" font="default" size="100%">Clin Cancer Res</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022 Nov 07</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;PURPOSE: &lt;/b&gt;Cancer patients display reduced humoral responses after double-dose COVID-19 vaccination while their cellular response is more comparable to that in healthy individuals. Recent studies demonstrated that a third vaccination dose boosts these immune responses, both in healthy people and cancer patients. Due to the availability of many different COVID-19 vaccines, many people have been boosted with a different vaccine from the one used for double-dose vaccination. Data on such alternative vaccination schedules are scarce. This prospective study compares a third dose of BNT162b2 after double-dose BNT162b2 (homologous) versus ChAdOx1 (heterologous) vaccination in cancer patients.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;EXPERIMENTAL DESIGN: &lt;/b&gt;442 subjects (315 patients and 127 healthy) received a third dose of BNT162b2 (230 homologous vs 212 heterologous). Vaccine-induced adverse events (AE) were captured up to 7 days after vaccination. Humoral immunity was assessed by SARS-CoV-2 anti-S1 IgG antibody levels and SARSCoV-2 50% neutralization titers (NT50) against Wuhan and BA.1 Omicron strains. Cellular immunity was examined by analyzing CD4+ and CD8+ T cell responses against SARS-CoV-2 specific S1 and S2 peptides.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Local AEs were more common after heterologous boosting. SARS-CoV-2 anti-S1 IgG antibody levels did not differ significantly between homologous and heterologous boosted subjects (GMT 1755.90 BAU/mL [95% CI 1276.95-2414.48] vs 1495.82 BAU/mL (95% CI 1131.48-1977.46)). However, homologous boosted subjects show significantly higher NT50 values against BA.1 Omicron. Subjects receiving heterologous boosting demonstrated increased spike-specific CD8+ T cells, including higher IFNγ and TNFα levels.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;In cancer patients who received double-dose ChAdOx1, a third heterologous dose of BNT162b2 was able to close the gap in antibody response.&lt;/p&gt;
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