<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Isabelle Etienne</style></author><author><style face="normal" font="default" size="100%">Delphine Kemlin</style></author><author><style face="normal" font="default" size="100%">Nicolas Gemander</style></author><author><style face="normal" font="default" size="100%">Véronique Olislagers</style></author><author><style face="normal" font="default" size="100%">Alexandra Waegemans</style></author><author><style face="normal" font="default" size="100%">Emilie Dhondt</style></author><author><style face="normal" font="default" size="100%">Leo Heyndrickx</style></author><author><style face="normal" font="default" size="100%">Stéphanie Depickère</style></author><author><style face="normal" font="default" size="100%">Alexia Charles</style></author><author><style face="normal" font="default" size="100%">Maria Goossens</style></author><author><style face="normal" font="default" size="100%">Leen Vandermosten</style></author><author><style face="normal" font="default" size="100%">I Desombere</style></author><author><style face="normal" font="default" size="100%">Kevin K Ariën</style></author><author><style face="normal" font="default" size="100%">Pieter Pannus</style></author><author><style face="normal" font="default" size="100%">Christiane Knoop</style></author><author><style face="normal" font="default" size="100%">Arnaud Marchant</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Persistent defect in SARS-CoV-2 humoral and cellular immunity in lung transplant recipients.</style></title><secondary-title><style face="normal" font="default" size="100%">J Heart Lung Transplant</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024 Aug 10</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Lung transplant recipients (LTR) are susceptible to severe COVID-19 and had lower immune responses to primary SARS-CoV-2 vaccination as compared to the general population and to other solid organ transplant recipients. As immunity induced by booster vaccination and natural infection has increased since the beginning of the pandemic in the general population, immunity acquired by LTR is not well documented. Humoral and cellular immunity to SARS-CoV-2 was monitored in February and May 2023 in 30 LTR and compared to that of health care workers (HCW) and nursing home residents (NHR). LTR had significantly lower levels of SARS-CoV-2 binding and neutralizing antibodies and lower IFN-γ responses to Wuhan, Delta and XBB1.5 variants as compared to HCW and NHR. Humoral immunity decreased between the two visits whereas cellular immunity remained more stable. The persistent defect in SARS-CoV-2 immunity in LTR should encourage continued monitoring and preventive measures for this vulnerable population.&lt;/p&gt;
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