Résultats de la recherche - 131 results
Discovery and Development of an Advanced Lead for the Treatment of African Trypanosomiasis.
genotoxicity in an testing battery, and mode of action studies (i.e., genome-wide RNA interference library screening and metabolomics). Among the nucleoside analogues, analogue was curative in mouse models with ...
Physicochemical characterization and genotoxicity assessment of nanomaterials using new approach methodologies
BelTox, Issue The Belgian Society of Toxicology and Ecotoxicology, Ghent, Belgium (2024) Keywords: Copper Oxides Feed Additive food additive Food Sector genotoxicity Iron Oxides and Hydroxides Nanoparticles ...
Safety assessment of the substance 2,2'-oxydiethylamine for use in plastic food contact materials.
1000 Da containing the substance, the estimated migration of these oligomers would be 1.042 mg/kg. Genotoxicity studies were performed on the substance and on ...
VERMEER FCM: A tool integrating exposure and hazard modelling for chemicals migrating from food contact materials.
predicted by a recently developed migration model, whereas hazard predictions for genotoxicity, subchronic toxicity, reproductive and developmental toxicity and carcinogenicity are provided by QSAR models ...
A BMD-based strategy to assess the combined effects of genotoxicants
Department 6 & 7, Berlin, Germany (0) Keywords: genotoxicity Micronucleus test mixtures Mycotoxins Health Topics: Food consumption and food safety Consommation et sécurité alimentaires Voedselconsumptie ...
Safety assessment of the substances 'wax, rice bran, oxidised' and 'wax, rice bran, oxidised, calcium salt' for use in food contact materials.
fraction. The contact with dry food and food simulated by 20% ethanol were considered covered by the migration tests with aqueous simulants. Based on genotoxicity assays and compositional analyses, the ...
Occurrence and Synthesis Pathways of (Suspected) Genotoxic α,β-Unsaturated Carbonyls in Chocolate and Other Commercial Sweet Snacks.
structural alerts for genotoxicity. Ten of them (either commercially available or synthesized here by combinatorial chemistry) were first investigated throughout the chocolate-making process by ...
Occurrence and Synthesis Pathways of (Suspected) Genotoxic α,β-Unsaturated Carbonyls in Chocolate and Other Commercial Sweet Snacks
(2024) Keywords: aromas chocolate Cocoa furan-2(5H)-one genotoxicity αβ-unsaturated carbonyls Abstract: α,β-Unsaturated carbonyls are highly reactive and described as structural alerts for genotoxicity ...
Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals.
* Source: Chem Res Toxicol, Volume 37, Issue 3 (2024) Keywords: Animals Biomarkers Cell Line DNA Damage Gene Expression Profiling Humans Transcriptome Abstract: To modernize genotoxicity assessment and reduce ...
Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.
quinones altertoxin I (ATX-I), ATX- II, ATX- III, alterperylenol (ALP), and stemphyltoxin III (STTX- III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the ...