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Résultats de la recherche - 193 results
Positive epistasis of major low-cost drug resistance mutations rpoB531-TTG and katG315-ACC depends on the phylogenetic background of Mycobacterium tuberculosis strains.
epidemic. Here we analysed the transmission capacity of these strains in the context of their phylogenetic background and drug resistance mutations. The study collection included all multidrug resistant (MDR) ...
Model-Based Classification for Digital PCR: Your Umbrella for Rain.
of precision, both at individual partition level and at the level of the global concentration. We illustrate our method on genetically modified organism, inhibition, dynamic range, and mutation ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
treatment of infected patients. Current TB drug resistance research is mainly focused on the genomic level, using WGS to search for resistance-causing mutations. However, transcriptional analyses can be ...
Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria.
Proteins Genotype Genotyping Techniques Humans Microbial Sensitivity Tests Mutant Proteins Mutation Mycobacterium Mycobacterium tuberculosis Rifampin Terminology as Topic Abstract: The rpoB gene codes for ...
Incorporation of the influenza A virus NA segment into virions does not require cognate non-coding sequences.
restored. Sequencing revealed that the replacing 5' NC sequence length drove the type of mutations obtained. With sequences longer than the original, point mutations in the coding region with or without ...
Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts
n-Tetracosanol Abstract: BACKGROUND: Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may ...
Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines.
highly attenuated, safer vaccines was evident after the development of the BTV reverse-genetics system that allows the introduction of targeted mutations in the virus genome. We targeted an essential gene ...
The correlation between antimutagenic activity and total phenolic content of extracts of 31 plant species with high antioxidant activity.
BACKGROUND: Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. There is increasing evidence that cancer and other mutation-related diseases can be ...
Genetic elements associated with antimicrobial resistance among avian pathogenic Escherichia coli.
TEM), chloramphenicol (cat1), kanamycin (aphA1), and sulphonamide (sul1 and sul2). Among ciprofloxacin-resistant isolates, the S83L mutation was the most frequently substitution observed in the quinolone ...
The Vitotox and ToxTracker assays: a two-test combination for quick and reliable assessment of genotoxic hazards
Source: Mutation research, Volume 810, Number 21 (2016) Keywords: an analysi analysis approach AS assessment chemicals Combination cosmetic Development Europe Follow up FOLLOW-UP genotoxicity hazard health ...