<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Qiu,Z.</style></author><author><style face="normal" font="default" size="100%">Dillen,C.</style></author><author><style face="normal" font="default" size="100%">Hu,J.</style></author><author><style face="normal" font="default" size="100%">H. Verbeke</style></author><author><style face="normal" font="default" size="100%">Struyf,S.</style></author><author><style face="normal" font="default" size="100%">J. Van Damme</style></author><author><style face="normal" font="default" size="100%">Opdenakker,G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Immunobiology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">chemokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibroblast</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-17</style></keyword><keyword><style  face="normal" font="default" size="100%">Matrix metalloproteinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Monocyte chemotactic protein-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Tissue inhibitor of metalloprotease</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">0/0/2009</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">842</style></number><volume><style face="normal" font="default" size="100%">214</style></volume><pages><style face="normal" font="default" size="100%">835 - 842</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Interleukin 17 (IL-17) is a proinflammatory cytokine, produced only by activated lymphocytes, but with a broad cellular host range. The effects of IL-17 on fibroblasts were investigated by analysis of the induction of chemokine and matrix metalloprotease (MMP) mRNA levels by RT-PCR. IL-17 stimulated CC chemokine (monocyte chemotactic protein-1; MCP-1/JE) and CXC (KC, MIP-2) chemokine and TIMP-1 mRNA expression in fibroblastoid L929 cells. In normal mouse embryonic fibroblasts (MEF) this induction profile by IL-17 was extended with the mRNAs encoding the chemokine granulocyte chemotactic protein-2 (GCP-2) and the proteases MMP-3, MMP-9 and MMP-13. The MMP-9 and GCP-2 induction by IL-17 in MEF, and the absence of induction in L929 cells, were corroborated by gelatin zymography and ELISA, respectively. The induction of MCP-1/CCL2 by IL-17 was confirmed in human diploid fibroblasts. We conclude that IL-17 regulates differentially chemokine and MMP expression by normal and transformed fibroblasts and is indirectly capable of attracting both monocytes and neutrophils to the inflammatory focus&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">9-10</style></issue><custom1><style face="normal" font="default" size="100%">38862</style></custom1><section><style face="normal" font="default" size="100%">835</style></section></record></records></xml>