<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ti Thu Ha Nguyen</style></author><author><style face="normal" font="default" size="100%">Seppe Segers</style></author><author><style face="normal" font="default" size="100%">M. Ledent</style></author><author><style face="normal" font="default" size="100%">Roel Anthonissen</style></author><author><style face="normal" font="default" size="100%">Luc Verschaeve</style></author><author><style face="normal" font="default" size="100%">M. Hinsenkamp</style></author><author><style face="normal" font="default" size="100%">J.-F. Collard</style></author><author><style face="normal" font="default" size="100%">Veronique Feipel</style></author><author><style face="normal" font="default" size="100%">Birgit Mertens</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of long-term exposure to 50 Hz magnetic fields on cell viability, genetic damage, and sensitivity to mutagen-induced damage.</style></title><secondary-title><style face="normal" font="default" size="100%">Heliyon</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2023 Mar</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Until today, it remains controversial whether long-term exposure to extremely low-frequency magnetic fields (ELF-MF) below the legislative exposure limits could result in adverse human health effects. In the present study, the effects of long-term MF exposure on three different study endpoints (cell viability, genetic damage, and sensitivity to damage induced by known mutagens) were investigated in the human B lymphoblastoid (TK6) cell line. Cells were exposed to 50&amp;nbsp;Hz&amp;nbsp;MF at three selected magnetic flux densities (i.e., 10, 100, and 500&amp;nbsp;μT) for different exposure periods ranging from 96h up to 6 weeks. Cell viability following MF exposure was assessed using the ATP-based cell viability assay. Effects of MF exposure on cell genetic damage and cell sensitivity to mutagen-induced damage were evaluated using the alkaline comet assay and the cytokinesis block micronucleus assay. The results showed that long-term exposure up to 96h to 50&amp;nbsp;Hz&amp;nbsp;MF at all tested flux densities could significantly increase TK6 cell viability. In contrast, long-term MF exposure did not affect cell genetic damage, and long-term pre-exposure to MF did not change cell sensitivity to damage induced by known mutagens. At certain time points, statistically significant difference in genotoxicity test results were observed between the MF-exposed cells and the control cells. However, these observations could not be confirmed in the repeat experiments, indicating that they are probably not biologically significant.&lt;/p&gt;
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