<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zulu, Gideon</style></author><author><style face="normal" font="default" size="100%">Dominik Stelzle</style></author><author><style face="normal" font="default" size="100%">Gabriël, Sarah</style></author><author><style face="normal" font="default" size="100%">Trevisan, Chiara</style></author><author><style face="normal" font="default" size="100%">Inge Van Damme</style></author><author><style face="normal" font="default" size="100%">Mubanga, Chishimba</style></author><author><style face="normal" font="default" size="100%">Schmidt, Veronika</style></author><author><style face="normal" font="default" size="100%">Bernard J Ngowi</style></author><author><style face="normal" font="default" size="100%">Tamara M Welte</style></author><author><style face="normal" font="default" size="100%">Magnussen, Pascal</style></author><author><style face="normal" font="default" size="100%">Charlotte Ruether</style></author><author><style face="normal" font="default" size="100%">Agnes Fleury</style></author><author><style face="normal" font="default" size="100%">Dorny, Pierre</style></author><author><style face="normal" font="default" size="100%">Bottieau, Emmanuel</style></author><author><style face="normal" font="default" size="100%">Isaac K Phiri</style></author><author><style face="normal" font="default" size="100%">Kabemba E Mwape</style></author><author><style face="normal" font="default" size="100%">Winkler, Andrea S</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">SOLID consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Neurocysticercosis Prevalence and Characteristics in Communities of Sinda District in Zambia: A Cross-Sectional Study.</style></title><secondary-title><style face="normal" font="default" size="100%">J Epidemiol Glob Health</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADOLESCENT</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">cross-sectional studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">middle aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurocysticercosis</style></keyword><keyword><style  face="normal" font="default" size="100%">prevalence</style></keyword><keyword><style  face="normal" font="default" size="100%">Taenia solium</style></keyword><keyword><style  face="normal" font="default" size="100%">Tomography, X-Ray Computed</style></keyword><keyword><style  face="normal" font="default" size="100%">Young adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Zambia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2024 Sep</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;This study aimed at describing the epidemiology of (neuro)cysticercosis as well as its clinical and radiological characteristics in a Taenia solium endemic district of Zambia.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6-27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4-21.1%) in the study population and 38.0% (95% CI 5.2-87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34-11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1-6] versus 2.5 [IQR 1-5.3], p = 0.64). Eight (23%) of the 35 TS POC CC+ participants with NCC had active stage lesions; in contrast none of the TS POC CC- participants was diagnosed with active NCC.&lt;/p&gt;

&lt;p&gt;&lt;b&gt;CONCLUSION: &lt;/b&gt;NCC is common in communities in the Eastern province of Zambia, but a large proportion of people remain asymptomatic.&lt;/p&gt;
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