Long-term memory response after a single intramuscular rabies booster vaccination, 10-24 years after primary immunization.
Ziekten en gezondheid in kaart brengen
Peer reviewed scientific article
Engels
SCIENSANO
Auteurs
Cornelis A De Pijper [1]; Annefleur C Langedijk [2]; Sanne Terryn [3]; Steven Van Gucht [4]; Martin P Grobusch [5]; Abraham Goorhuis [6]; Cornelis Stijnis [7]Trefwoorden
Article written during project(s) :
Samenvatting:
BACKGROUND: To date, published data regarding long-lasting immunological rabies memory after a pre-exposure prophylaxis (PrEP)-schedule are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.
METHODS: For this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7 and 14 after one single intramuscular booster.
RESULTS: All 28 participants responded adequately regardless route of administration or (2-dose vs. 3-dose) PrEP-regimen. C…