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Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors31058
Villeret,V.; Wohlkonig,A.; Wintjens,R.; Soror,S.H.; Christophe,T.; Jeon,H.K.; Locht,C.; Brodin,P.; Deprez,B.; Baulard,A.R.; Willand,N. Source: J.Med.Chem., Volume 55, Issue 1, Number 83, p.68- 83 (2012) ...
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Locht, Camille; Brodin, Priscille; Gitzinger, Marc; Déprez, Benoit; Willand, Nicolas; Baulard, Alain R Source: Science, Volume 355, Issue 6330, p.1206-1211 (2017) Abstract: Antibiotic resistance is one of ...
The small-molecule SMARt751 reverses resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Piveteau; Kiass, Mehdi; Vanessa Mathys; Karine Soetaert; Véronique Megalizzi; Tanina, Abdalkarim; Wintjens, René; Antoine, Rudy; Brodin, Priscille; Delorme, Vincent; Moune, Martin; Djaout, Kamel; Stéphanie ...