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Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
Drug Resistance, Viral Enzyme Inhibitors Hepacivirus Models, Molecular Mutation Protein Conformation Pyridines RNA Replicase Virus Replication Abstract: 2,6-Bis(benzimidazol-2-yl)pyridine (BBP / CSFA-0) ...
Infectious Bursal Disease: a complex host-pathogen interaction.
virus, IBDV has a high mutation rate and may thus give rise to viruses with a modified antigenicity or increased virulence, as emphasized during the last decades. The molecular basis of pathogenicity and ...
Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.
in the RdRp. Interestingly, the frequency of the mutations situated in close proximity to a region involved in antiviral resistance in CSFV and bovine viral diarrhea virus (BVDV) was elevated compared ...
What's in a strain? Viral metagenomics identifies genetic variation and contaminating circoviruses in laboratory isolates of pigeon paramyxovirus type 1.
Notably, mutations that were previously associated with pathogenicity in chickens were identified as minor sequence variants in one parent laboratory strain. A phylogenetic analysis of the consensus PPMV-1 ...
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
This was paralleled by an increase in β-cell proliferation and mass. The mutation also increased β-cell insulin content, proinsulin immunostaining, glucose-induced Ca(2+) uptake, and β-cell resistance to ...
Fine quantification of avian influenza H5N1 escape mutant quasispecies populations using mutation-specific real-time PCR.
Adaptation, Physiological Animals Chick Embryo Evolution, Molecular Gene Expression Regulation, Viral Genes, Viral Influenza A Virus, H5N1 Subtype Mutation polymerase chain reaction RNA, Viral Sequence ...
Identification of a dominant epitope in the hemagglutinin of an Asian highly pathogenic avian influenza H5N1 clade 1 virus by selection of escape mutants.
Molecular Mutation Neutralization Tests Viral Proteins Abstract: H5N1 avian influenza virus has caused widespread infection in poultry and wild birds, and has the potential to emerge as a pandemic threat to ...
Evaluation of different serologic markers for the early detection of avian influenza infection in chickens.
influenza viruses can mutate during circulation in poultry and emerge as high pathogenicity avian influenza variants. It is therefore essential to monitor the field situation continuously to detect low ...
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Mutation, Missense RNA Replicase triazoles Viral Proteins Virus Replication Yellow fever virus Abstract: [7-[3-(1,3-Benzodioxol-5-yl)propyl]-2-(2-furyl)-7H-pyrazolo [4,3-e][1,2,4]triazolo ...
The polymeric stability of the Escherichia coli F4 (K88) fimbriae enhances its mucosal immunogenicity following oral immunization.
Escherichia coli Infections Escherichia coli Vaccines Fimbriae, Bacterial Immunity, Mucosal Immunization Intestinal Mucosa Mutation Polymers Swine Swine Diseases Abstract: Only a few vaccines are commercially ...