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Résultats de la recherche - 64 results
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
aethiops Enterovirus B, Human HeLa Cells Humans Poliovirus RNA-Dependent RNA Polymerase Viral Proteins Abstract: The genus Enterovirus of the family Picornaviridae contains many important human pathogens ...
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
pathogenic member of the genus Aphthovirus (family Picornaviridae) that is only to be manipulated in high-containment facilities, thus complicating research on and discovery of antiviral strategies against the ...
Coupling of drug containing liposomes to microbubbles improves ultrasound triggered drug delivery in mice.
microbubbles by coupling drug containing liposomes to the surface of microbubbles. Until now the advantages of this drug loading strategy have only been demonstrated in vitro. Therefore, in this paper, ...
Development, validation and evaluation of added diagnostic value of a q(RT)-PCR for the detection of genotype A strains of small ruminant lentiviruses.
Spain, Portugal, UK, Iceland, Finland and USA were found positive. Samples known to contain ‘ CAEV like’ SRLV from France and Spain were not identified as positive. Combined serological and PCR analysis of ...
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A.
M2 e- VLP s containing nucleic acids induced a stronger, Th1-biased antibody response compared to particles lacking nucleic acids. The former also induced a stronger M2 e-specific CD4 (+) T cell ...
Influence of isolation methods on the occurrence of plasmid-carrying Yersinia enterocolitica serotype O:3 in slaughter pig tonsils, faeces and carcass surface swabs.
virulence plasmid. Isolates obtained from faeces were more likely to contain the virulence plasmid than isolates from tonsils and carcass swabs. To obtain reliable results regarding the presence of ...
Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.
shifted significantly when an antiviral resistant variant was analyzed. In total 22nt changes were found resulting in 14 amino acid changes whereby each genome copy contained at least 2 amino-acid changes ...
Detection of Schmallenberg virus in different Culicoides spp. by real-time RT-PCR.
Polymerase Chain Reaction Seasons Abstract: To identify possible vectors of Schmallenberg virus (SBV), we tested pools containing heads of biting midges (Culicoides) that were caught during the summer and ...
Evaluation of classical swine fever virus antibody detection assays with an emphasis on the differentiation of infected from vaccinated animals.
Therefore, it is not suitable for use with the chimeric marker vaccines tested. The PrioCHECK CSFV Erns was the only ELISA suitable for use in DIVA with marker vaccines containing Erns proteins from ruminant ...
DNase SISPA-next generation sequencing confirms Schmallenberg virus in Belgian field samples and identifies genetic variation in Europe.
generation sequencing. An in vitro transcribed RNA was used to construct a standard curve allowing the quantification of viral RNA in the field samples. Two field samples of aborted lambs containing 7.66 and ...