CMV: serologic analyses

Description of tests

The NRC will choose to perform one or more of the following tests:

• IgG and IgM antibodies using one or two different techniques
• IgG avidity determination
• Determination of IgG against different CMV antigens using immunoblot

Purpose of the tests

Interpreting the serological profile according to the gestational age at the time of blood collection. To advise on the possibility of primary infection in pregnancy.

Criteria for performing this test

• The reference centre only confirms serological analyses in pregnant patients. Application forms must be completed in full.
• The reference centre will perform the test(s) it deems necessary. As a rule, IgG and IgM are determined first and, depending on the results of this initial screening, additional tests deemed necessary for interpretation of the serological profile may be performed.
• Application without clinical and biological information will not be performed.

Instructions for samples and transport

At least 1 ml of serum, is required to allow all necessary tests to be performed:

• For unfrozen serum: transport at room temperature
• For frozen serum: preferably transport in frozen condition.

Unacceptable requests

• Incomplete request form
• Insufficient sample
• Sample not suitable for analysis
• Application does not meet the criteria. 

Turn around time

Depends on the number of confirmation tests required. Response time can be up to 1 week.

Reporting of test results 

The laboratory reports the results and comments and sends it to the requesting laboratory by post or via medibridge (UZBrussels).