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  3. Development of a pyrosequencing assay for rapid assessment of quinolone resistance in Acinetobacter baumannii isolates36532

Development of a pyrosequencing assay for rapid assessment of quinolone resistance in Acinetobacter baumannii isolates36532

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1016/j.mimet.2011.04.007

Authors

Deccache,Y.; Irenge,L.M.; Savov,E.; Ariciuc,M.; Macovei,A.; Trifonova,A.; Gergova,I.; Ambroise,J.; R. Vanhoof; Gala,J.L.

Keywords

  1. 0
  2. a
  3. Absence
  4. acinetobacter
  5. Acinetobacter baumannii
  6. Acinetobacter Infections
  7. article
  8. assessment
  9. Bacterial Proteins
  10. Base Sequence
  11. Belgian
  12. Belgium
  13. Brussels
  14. Correlation
  15. Development
  16. Dna
  17. DNA Gyrase
  18. DNA Topoisomerase IV
  19. drug effects
  20. Drug Resistance,Bacterial
  21. electronic
  22. enzymology
  23. EVALUATION
  24. gene
  25. genetics
  26. Humans
  27. im
  28. IS
  29. isolation & purification
  30. journal
  31. Laboratories
  32. methods
  33. Microbial Sensitivity Tests
  34. microbiology
  35. Molecular Sequence Data
  36. Mutation
  37. pharmacology
  38. protein
  39. Proteins
  40. Quinolines
  41. Quinolones
  42. region
  43. Research
  44. Research Support
  45. resistance
  46. SB - IM
  47. Sequence Analysis,DNA
  48. study

Abstract:

Rapid and reliable assessment of Acinetobacter baumannii resistance to quinolones was successfully achieved through pyrosequencing of the gyrA and parC quinolone-resistance determining regions. A strong correlation was found between quinolone resistance and mutations in gyrA codon 83 and/or in the parC gene (codons 80 or 84). Absence of QRDR mutations was associated with susceptibility to quinolones
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