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Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers
Tuberculosis; Antimicrobial resistance; Diagnosis; RNA Biomarkers Abstract: Background Efficient management of drug-resistant tuberculosis relies on fast diagnostics. To accelerate phenotypic drug susceptibility ...
Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis.
global phenotypic changes in circulating CD8 T cells after experimental infection of calves. T cell receptor repertoire together with transcriptomics and epigenomics analyses demonstrated an oligoclonal ...
Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.
rplDV, 23S rRNA and acrB genes using ResFinder v4.0, AMRF inder Plus and custom scripts. Genotype-phenotype concordance was determined for all isolates. Transferability of mef(C)-mph(G)-carrying plasmids ...
Allele Frequencies of Genetic Variants Associated with Varroa Drone Brood Resistance (DBR) in Apis mellifera Subspecies across the European Continent.
same phenotype on a population-wide scale in Flanders, Belgium. As the properties of some variants varied between the two studies, one hypothesized that the difference in genetic ancestry of the sampled ...
Hybrid Immunity Overcomes Defective Immune Response to COVID-19 Vaccination in Kidney Transplant Recipients
responses, a phenotype called hybrid immunity. In this study, we explored the potential influence of immune suppression on hybrid immunity in KTR s. Methods Eighty-two KTR s, including 59 SARS-CoV-2-naïve ...
Combined deficient response to polysaccharide-based and protein-based vaccines predicts a severe clinical phenotype
Publication Type: Peer reviewed scientific article Authors: Cockx, Maaike; Haerynck, Filomeen; Hoste, Levi; Schrijvers, Rik; Van der Werff ten Bosch, Jutte; Dillaerts, Doreen; Thomas, Debby; Schaballie, Heidi; Bucciol, Giorgia; Robberechts, Wiert; Patel, ...
Comparing frailty prevalence between countries: validation of the Global Burden of Disease study Frailty Index (GBD-FI) in the survey of health, ageing and retirement in Europe
in Europe (SHARE). A 20-item modified GBD- FI was compared with established frailty measures: a 70-item frailty index (FI-70), the Clinical Frailty Scale (CFS), Frailty Phenotype (FP) and SHARE- FI. ...
Targeted Chromosomal Barcoding Establishes Direct Genotype-Phenotype Associations for Antibiotic Resistance in Mycobacterium abscessus.
antibiotic resistance phenotype. To establish a direct genotype-phenotype relationship of this mutation which results in a Asp-to-Ala change at position 29 (D29A), we developed a recombineering-based method ...
Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants.
inhibition assay allows the phenotypical identification of resistant strains; however, this test often has limited sensitivity with high variability depending on the virus strain, drugs and assays. Once ...
Pulmonary Aspergillosis in Humboldt Penguins—Susceptibility Patterns andMolecular Epidemiology of Clinical and Environmental Aspergillus fumigatus Isolates from a Belgian Zoo
Isolates displaying phenotypic resistance against at least one medical azole were systematically screened for mutations in the cyp51A gene. A total of 14 (13.6%) ARAF isolates were identified from the ...