General concept
The analyses of clinical pathology prescribed in the context of rare diseases and that are not available in Belgium, can be outsourced to foreign medical laboratories.
In this context, an invoice can be sent to Sciensano (nathalie.vandevelde@sciensano.be) in order to obtain reimbursement of the transport and analysis costs for the outsourced samples.
Examples of analyses outsourced to foreign laboratories
Below you will find a non-exhaustive list of medical analyses that can be outsourced and of foreign laboratories that perform them.
Congenital disorders of glycosylation (CDG)
Parameter: Apolipoprotein C-III glycoforms in plasma by capillary zone electrophoresis
Lab: Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Lab: Laboratoire de biochimie A métabolique et cellulaire, CHU Paris Nord-Val de Seine- Hôpital Xavier Bichat-Claude Bernard, Paris, France
Parameter: Mass spectrometry-based characterization of plasma (or serum) N‐linked glycans
Lab: Laboratoire de biochimie A métabolique et cellulaire, CHU Paris Nord-Val de Seine- Hôpital Xavier Bichat-Claude Bernard, Paris, France
Parameter: Analysis of serum proteoglycan bikunin
Lab: Laboratoire de biochimie A métabolique et cellulaire, CHU Paris Nord-Val de Seine- Hôpital Xavier Bichat-Claude Bernard, Paris, France
Molybdenum cofactor (MOCO) deficiency
Parameter: Measurement of sulfite oxidase activity in fibroblasts; analysis of genes MOCS1 and MOCS2
Lab: Department of Inborn Errors of Metabolism and Neonatal Screening Center of Biology and Pathology Est-CHU Lyon, Bron, France
Niemann-Pick disease type C
Parameter: Filipin test on cultured fibroblasts
Lab: Centre de biotechnologie cellulaire, Centre de Biologie et Pathologie Est CHU de Lyon HCL — GH Est, Bron, France
Other analyses
Parameter: Measurement of urinary D- and L-2 hydroxyglutarate enantiomers
Lab: Laboratory Genetic Metabolic Diseases Academic Medical Center Amsterdam, The Netherlands
Parameter: Determination of S-Adenosylmethionine and S-Adenosylhomocysteine in plasma and CSF
Lab: Laboratory Genetic Metabolic Diseases Academic Medical Center Amsterdam, The Netherlands
Parameter: Biochemical diagnosis of Glutaric Aciduria (Glutaryl-CoA Dehydrogenase activity)
Lab: Laboratory Genetic Metabolic Diseases Academic Medical Center Amsterdam, The Netherlands
Parameter: Transcobalamins assessment in serum
Lab: Biochemistry and Molecular Biology Laboratory CHU de Nancy — Hôpitaux de Brabois Vandoeuvre-lès-Nancy, France
Parameter: Trimethylamine assessment in urine
Lab: Metabolic laboratory, Center for Metabolic Diseases University Children´s Hospital Heidelberg, Germany
Lab: Laboratory for Diagnostics, Radboud UMC, Nijmegen, The Netherlands
Lab: Laboratoire Biochimie génopathies, Pôle de Biologie Pathologie Génétique, CHU de Lille, France
Parameter: Pterins assessment in plasma and cerebrospinal fluid
Lab: Metabolic laboratory, Center for Metabolic Diseases University Children´s Hospital Heidelberg, Germany
Parameter: Biogenic amines assessment in CSF (Serotonin [5-hydroxytryptamine; 5-HT], 5-hydroxyindoleacetic acid [5‐HIAA], homovanillic acid [HVA], dopamine [3,4-dihydroxyphenethylamine; DA], 3-O methyldopa [3-OMD], 5-hydroxytryptophan [5‐HTP])
Lab: Metabolic laboratory, Center for Metabolic Diseases University Children´s Hospital Heidelberg, Germany
Contact
Scientific manager
Nathalie Vandevelde
+32 2 642 55 89
nathalie.vandevelde@sciensano.be
Other contacts
Ynse Van de Maele
+32 2 642 55 24
ynse.vandemaele@sciensano.be
Secretary
+32 2 642 55 22
QL_secretariat@sciensano.be
Rue Juliette Wytsman 14 • 1050 Brussels