JA PCM - Joint Action Personalised Cancer Medicine

For European projects: please add few lines to answer the question: “what does Sciensano within this project?”, could be a list of Work packages in which we are involved.

The goal of this Joint Action (JA) is to make personalised cancer care more accessible and well-understood across Europe. The aim is to develop healthcare strategies that follow individuals throughout their lives, whether they are healthy, battling cancer, or living as cancer survivors. The partners in this initiative agree that the best outcomes for patients come from addressing prevention, diagnosis, treatment, and follow-up together as part of an integrated approach.

The JA will focus on three main areas:

1. personalised prevention and early detection,
2. personalised medicine,
3. personalised follow-up care.

The project builds on successful past projects like CAN.HEAL  and PCM4EU to explore key topics such as cancer prevention pathways, genetic testing, new treatment models, and cutting-edge technologies like liquid biopsy and remote monitoring. Alongside these, there will be supporting activities around training, ethical issues, and health technology assessment. At the end of this initiative, we will have a ‘PCM in Europe’ roadmap and a sustainability plan that will align with Europe’s broader cancer strategy, the European Beating Cancer Plan.

The specific outcomes of the identified objectives are:

• Improved access to PCM: Ensuring broader availability of PCM for prevention, early detection, diagnosis, treatment, and survival across the EU.
• Best Practices sharing: Facilitating the exchange of best practices in PCM, including the use of digital tools, molecular diagnostics, liquid biopsy (LB), and molecular tumor boards (MTB).
• Framework development: Establishing a framework to monitor and measure the increased uptake of PCM within the EU, ensuring its integration into cancer care systems.
• Knowledge enhancement: Expanding the understanding of PCM among healthcare professionals, cancer patients, and the general population, empowering them with critical information.
• Reduction of Disparities: Addressing and reducing disparities and inequalities in access to personalized cancer care, ensuring more equitable treatment across EU member states.

Sciensano’s involvement

The Cancer Center of Sciensano’s involvement in the project includes:

• Coordination
• Lead of WP2 on communication and dissemination
• Task lead in WP5 on minimal requirements of personalised cancer prevention in the EU
• Ethical, legal and social issues in WP6 ‘diagnosis’ and as co-lead of WP12 ‘ethical, legal and equity considerations’
• Contribution in WP8 on expanding the treatment space by access under systematic evidence-generation
• Co-lead WP9 ‘Digital innovation for improving survivorship care delivery’     

External partners

Belgium

• Centre hospitalier universitaire de Liège
• Cliniques universitaires Saint Luc
• Jessa Hospital
• Katholiek Universiteit Leuven
• Belgian Nuclear Research Centre
• Universiteit Gent
• Universiteit Ziekenhuis Antwerpen
• Vrij Universiteit Brussel — UZ Brussel
• Institut Jules Bordet

Bosnia and Herzegovina

• Clinical Center University of Sarajevo
• University Clinical Hospital Mostar

Croatia

• Klinički Bolnički Centar Sestre milosrdnice, eng. Sestre milosrdnice University Hospital Center
• Koalicija udruga u zdravstvu — Coalition of Associations in Health Care
• Ruđer Bošković Institute

Cyprus

• Health insurance Organisation
• Ogologiko Kentro Trapezas Kyprou

Czechia

• Institute of Hematology and Blood Transfusion (Ústav hematologie a krevní transfuze)
• Masaryk Memorial Cancer Institute

Denmark

• The Region of Southern Denmark
• Central Denmark Region, Aarhus University Hospital
• The North Denmark Region, Aalborg University Hospital
• Region Zealand

Estonia

• Tartu University (University of Tartu)
• IDA-TALLINNA KESKHAIGLA AS
• NORTH ESTONIA MEDICAL CENTRE FOUNDATION
• National Institute for Health Development — Tervise Arengu Instituut
• SIHTASUTUS TARTU ULIKOOLI KLIINIKUM

Finland

• HUS Group
• University of Oulu
• Wellbeing Services County of Pirkanmaa
• Wellbeing services county of North Savo
• Tampere University
• University of Helsinki
• University of Eastern Finland
• University of Turku

France

• Institut National du Cancer
• Centre Hospitalier Universitaire de Bordeaux
• Centre hospitalier universitaire de Limoges
• Centre hospitalier universitaire de Poitiers
• Centre de lutte contre le cancer Léon Berard
• Haute Autorité de Santé
• Centre de lutte contre le cancer Institut Curie
• Institut Gustave Roussy
• Institut National de la santé et de la recherche médicale
• Fédération nationale des centre de lutte contre le cancer
• Fédération Hospitalière de France

Germany

• Federal Institute for Drugs and Medical Devices
• Charité – Universitätsmedizin Berlin
• German Cancer Society
• University Medical Center Hamburg-Eppendorf
• University Hospital of Würzburg
• Universitätsmedizin Rostock
• Eberhard Karls University Tübingen
• UNIVERSITÄTSKLINIKUM Schleswig-Holstein

Greece

• 1st Regional Health Authority
• National Hellenic Research Foundation
• National and Kapodistrian University of Athens

Hungary

• National Institute of Oncology (NIO in Hungarian:OOI)

Iceland

• Landspitali University Hospital

Ireland

• Health Service Executive
• Beaumont Hospital
• Royal Collgte of Surgeons in Ireland
• St James’ Hospital
• St Vincent’s University Hospital
• University College Dublin
• University of Limerick

Italy

• Alleanza contro il cancro
• Aondazione policlinico universitario agostino gemelli — IRCCS
• Istituto europeo di oncologia
• Istituti fisioterapici ospitalieri — istituto regina elena — IRCCS
• Istituto nazionale tumori milano — IRCCS
• Istituto nazionale tumori  pascale napoli — IRCCS
• Azienda ospedaliera universitaria di bologna — IRCCS
• Istituto superiore di sanita
• Azienda unita’ socio-sanitaria locale n.4 — programma mattone internazionale salute
• Region Lombardia

Latvia

• Latvian Biomedical Research and Study Centre
• University of Latvia
• Riga East University Hospital
• Riga Stradins University
• Pauls Stradins Clinical University Hospital

Lithuania

• Lietuvos sveikatos mokslu universitetas
• Ministry of health of the republic of lithuania
• Nacionalinis vezio institutas
• Vilniaus universiteto ligonine santaros klinikos

Luxembourg

• Institut National du Cancer
• Centre François Baclesse
• Centre hospitalier du Nord
• Centre Hospitalier Emile Mayrisch
• Centre Hospitalier de Luxembourg
• Fondation Emile Mayrisch Croix-Rouge asbl
• Hopitaux Robert Schuman
• Luxembourg Institute of Health
• Luxembourg National Data Service
• Laboratoire national de santé

Malta

• Ministry for health and active ageing

Netherlands

• Erasmus Medical Centre
• Stichting Het Nederlands Kanker Instituut — Antoni van Leeuwenhoek Ziekenhuis
• Leiden University Medical Center

Norway

• Oslo University Hospital
• Norwegian Directorate of Health
• Norwegian Institute of Public Health
• Haukeland University Hospital
• Helse Stavanger

Poland

• Maria Sklodowska-Curie National Research Institute of Oncology
• Lower Silesian Oncology, Pulmonology and Hematology Center
• Medical University of Bialystok
• Medical University of Warsaw

Portugal

• Direção-Geral da Saúde / Directorate-General of Health
• Instituto Nacional de Saúde Doutor Ricardo Jorge / National Institute of Health Doutor Ricardo Jorge
• Instituto Português Oncologia de Lisboa Francisco Gentil- E.P.E.
• Instituto Português de Oncologia do Porto Francisco Gentil E.P.E.
• Instituto de Investigação e Inovação em Saúde da Universidade do Porto
• Instituto de patologia e imunologia molecular da universidade do Porto

Slovenia

• Institute of oncology Ljubljana

Spain

• Institut català d’oncologia
• Agència de Qualitat i Avaluació Sanitàries de Catalunya
• Fundación Instituto de Investigación Marqués de Valdecilla
• Instituto de Investigación Sanitaria La Fe
• Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
• Fundación para la Investigación del Hospital Clínico de la Comunidad Valenciana
• Servicio Cántabro de Salud
• Instituto de Salud Carlos III/CIBER-CIBERONC
• Consorcio Centro de Investigación Biomédica en Red
• Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III
• Departamento de Sanidad del Gobierno de Aragón
• Instituto Aragonés de Ciencias de la Salud
• Servizo Galego de Saúde
• Agencia Gallega para la Gestión del Conocimiento en Salud
• Hospital Infantil Universitario Niño Jesús (HIUNJ)
• Fundación para la Investigación Biomédica del Hospital Infantil Universitario Niño Jesús
• Vall d’Hebron Institute of Oncology
• Fundació Institut de Recerca Biomèdica

Sweden

• Socialstyrelsen / The National Board of Health and Welfare
• Karolinska Institutet
• Region Skåne / Skåne University Hospital
• Stiftelsen Stockholm School of Economics (SSE) Institute for Research
• Region Stockholm / Karolinska Universitetssjukhuset
• Linkoping Comprehensive Cancer Center
• Lund University

Ukraine

• National Cancer institute of the Ministry of Health of Ukraine

Moldova

• Institute of Oncology

Romania

• University of Medicine and Pharmacy “Carol Davila” Bucharest
• University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca
• The Genomic Research and Development Institute