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Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
Neyts, Johan; Paeshuyse, Jan Source: Antiviral Res, Volume 106, p.71-9 (2014) Keywords: Animals Antiviral Agents Benzimidazoles Cattle Cell Line Classical swine fever virus Diarrhea Virus 1, Bovine Viral ...
In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
Publication Type: Peer reviewed scientific article Authors: Osiceanu, Ana-Maria; Murao, Lyre Espada; Kollanur, Denny; Swinnen, Jan; Annebel De Vleeschauwer; David Lefebvre; Kris De Clercq; Neyts, ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
Lefebvre, David; Lanke, Kjerstin H W; Kris De Clercq; Hilgenfeld, Rolf; Neyts, Johan; van Kuppeveld, Frank J M Source: Antiviral Res, Volume 103, p.17-24 (2014) Keywords: 3C Viral Proteases Animals Antiviral ...
Intra-host variation structure of classical swine fever virus NS5B in relation to antiviral therapy.
Publication Type: Peer reviewed scientific article Authors: Andy Haegeman; Vrancken, Robert; Neyts, Johan; F. Koenen Source: Antiviral Res, Volume 98, Issue 2, p.266-72 (2013) Keywords: Amino Acid ...
Diagnostic performance and application of two commercial cell viability assays in foot-and-mouth disease research.
Publication Type: Peer reviewed scientific article Authors: Willems, Tom; David Lefebvre; Neyts, Johan; Kris De Clercq Source: J Virol Methods, Volume 173, Issue 1, p.108-14 (2011) Keywords: Animals ...
Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor.
Marie-Frédérique; Neyts, Johan; F. Koenen Source: J Gen Virol, Volume 90, Issue Pt 6, p.1335-42 (2009) Keywords: Administration, Oral Animals Antiviral Agents Classical Swine Fever Classical swine fever virus ...
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Teulade, Jean-Claude; Herdewijn, Piet; Puerstinger, Gerhard; F. Koenen; Pierre Kerkhofs; Baraldi, Pier Giovanni; Neyts, Johan Source: Antiviral Res, Volume 82, Issue 3, p.141-7 (2009) Keywords: Amino Acid ...
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Carine; Li, Tong; Mittendorfer, Harald; F. Koenen; Pierre Kerkhofs; De Clercq, Erik; Herdewijn, Piet; Puerstinger, Gerhard; Gueiffier, Alain; Chavignon, Olivier; Teulade, Jean-Claude; Neyts, Johan Source: ...
2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus.
Publication Type: Peer reviewed scientific article Authors: Goris, Nesya; De Palma, Armando; Toussaint, Jean-François; Musch, Ina; Neyts, Johan; Kris De Clercq Source: Antiviral Res, Volume 73, ...
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Rozenski, Jef; Gil, Laura H V G; Letellier, Carine; Lanford, Robert; Canard, Bruno; F. Koenen; Pierre Kerkhofs; Donis, Ruben O; Herdewijn, Piet; Watson, Julia; De Clercq, Erik; Puerstinger, Gerhard; Neyts, ...