Search results - 7 results
Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers
molecules that enhance antibiotic efficacy, and investigated its applicability in macrophage models to assess Mtb’s intracellular stress responses to drugs. Findings Antituberculosis drugs trigger distinct ...
A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study.
among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among patients from the Horn of Africa ...
Virulence and immunogenicity of genetically defined human and porcine isolates of M. avium subsp. hominissuis in an experimental mouse infection
lungs, spleen and liver and mycobacteria specific spleen cell IFN-γ, IL-10 and IL-17 production as well as serum antibody responses were analyzed. Isolates varied in virulence, with human and porcine ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
However, transcriptional analyses can be a powerful tool as well. Analyses on susceptible strains provide information on the response to the stress a drug is causing, showing which mechanisms are activated ...
Global transcriptional analyses of Mycobacterium tuberculosis using old and new drugs
a powerful tool as well. Analyses on susceptible strains provide information on the response to the stress a drug is causing, showing which mechanisms are activated to counter the effect of the drug. This ...
RNA-based drug susceptibility testing of Mycobacterium tuberculosis
Background Multidrug resistance of Tuberculosis strains (MDR- TB) are one of the major WHO health concerns. One of the challenges that hampers the effective response to MDR- TB is the long turnaround time of ...
Transcriptional profiling of Mycobacterium tuberculosis suggests respiratory poisoning upon exposure to delamanid
counter the spread of multidrug resistant TB, the discovery and characterization of new drugs is essential. In this study, the transcriptional response of two Mycobacterium tuberculosis strains to ...