Search results - 101 results
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.
Annotation Point Mutation Protein Interaction Maps Abstract: The current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid ...
Encompassing new use cases- level 3.0 of the HUPO-PSI format for molecular interactions.
Y Yehudi; Kim Van Roey; S Orchard Source: BMC Bioinformatics, Volume 19, Issue 1 (2018) Keywords: Databases, Protein Humans Mutation Protein Interaction Maps Proteome Proteomics Systems Biology Abstract: ...
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei.
fluoroquinolone-resistant S. sonnei. We reaffirm that extant resistant organisms belong to a single clonal expansion event. Our results indicate that sequential accumulation of defining mutations (gyrA- S83L, parC- S80I, and ...
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
Egypt before disseminating into Northern, Southern and Western Africa, then to the Middle East, Asia and the European Union. The MDR clone has since accumulated various substitution mutations in the ...
Whole-genome-based phylogenomic analysis of the Belgian 2016-2017 influenza A(H3N2) outbreak season allows improved surveillance.
Organization (WHO) and European Centre for Disease Prevention and Control (ECDC) guidelines is based on combining certain genotypic amino acid mutations and phylogenetic analysis. Next-generation sequencing ...
The small-molecule SMARt751 reverses resistance to ethionamide in acute and chronic mouse models of tuberculosis.
and chronic TB. SMAR t751 also restored full efficacy of ethionamide in mice infected with strains carrying mutations in the gene, which cause ethionamide resistance in the clinic. SMAR t751 was shown ...
The AMR-ARRAY: A modular bead array detecting β-lactam, (fluoro) quinolone, colistin, aminoglycoside and macrolide resistance determinants in Gram-negative bacteria.
Macrolides Quinolones Abstract: The aim of this study was to develop a highly multiplexed bead array to detect genes and/or mutations frequently associated with resistance to antimicrobials of the β-lactam, ...
Characterization of In Vivo acquired resistance of Mycoplasma hyopneumoniae to macrolides and lincosamides.
rDNA. Therefore, high MIC s were observed for all strains, although the MIC s for the resistant strain were clearly increased. An additional, acquired A 2058 G point mutation was found in the 23S rRNA ...
Resistance mechanism against fluoroquinolones in Mycoplasma hyopneumoniae field isolates.
Fluoroquinolones Genes, Bacterial Microbial Sensitivity Tests Mycoplasma hyopneumoniae Point Mutation polymerase chain reaction Sequence Analysis, DNA Swine Abstract: The quinolone resistance-determining regions ...
Optimization and Application of a Multiplex Digital PCR Assay for the Detection of SARS-CoV-2 Variants of Concern in Belgian Influent Wastewater.
of emerging SARS-CoV-2 variants of concern (VOC) in influent wastewater (IWW) samples. Key mutations were targeted in the different VOC strains, including SΔ69 /70 deletion, N501Y, SΔ241 and SΔ157. The ...