Search results - 24 results
EBoD-FL. Guidelines for mapping the environmental burden of disease in Flanders, 2023
a summary measure that combines both mortality and morbidity. Given the extensive list of potential risk factor-health outcome pairs, a set of priorities was defined in terms of environmental stressors and ...
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.
key study elements regarding study setup, methodology, techniques, and (qualitative and quantitative) outcomes. Subsequent synthesis will consist of an explorative meta-analysis of possible ...
An AOP-based IATA to pave the way toward animal-free genotoxicity testing
Publication Type: Scientific poster, presentation or proceeding Authors: Birgit Mertens Source: Joint 3R Symposium 2023, Brussels, Belgium (2023) Keywords: adverse outcome pathways genotoxicity ...
Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake
Birgit Mertens Source: 57th Congress of the European Societies of Toxicology, Ljubljana, Slovenia (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment ...
Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity- A roadmap for regulatory uptake
Birgit Mertens Source: Joint 3R Symposium, Brussels, Belgium (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to testing and assessment (IATA) pollutants Health Topics: ...
Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity Assessment
Martin Paparella Source: 12th World Congress on Alternatives and Animal Use in the Life Sciences, Nigara falls, Canada (2023) Keywords: adverse outcome pathways Cardiotoxicity Integrated approaches to ...
Novel prediction models for genotoxicity based on biomarker genes in human HepaRG™ cells.
the outcomes of both prediction models. This research demonstrates that the combination of gene expression data with supervised machine learning algorithms can contribute to the ongoing paradigm shift ...
Development of an AOP-based IATA for genotoxicity
O Armant; C Pachoulide; H Bouwmeester; G Raitano; E Benfenati; E Wyrzykowska; M Stepnik; T Puzyn; M Audebert; Birgit Mertens Source: EEMGS meeting (2023) Keywords: adverse outcome pathways genotoxicity ...
EBoD-FL. Guidelines for mapping the environmental burden of disease in Flanders
a summary measure that combines both mortality and morbidity. Given the extensive list of potential stressor-health outcome pairs, a set of priorities was defined in terms of environmental stressors and ...
In Silico Methods for Chromosome Damage.
prediction tools for chromosome damage is applied on a dataset of pharmaceuticals. Examples of the different outcomes obtained with the in silico battery are provided and briefly discussed. Furthermore, ...