Last updated on 23-8-2019 by Anonymous (niet gecontroleerd)
Public Access
Published
Peer reviewed scientific article
SCIENSANO
Auteurs
K Huygen; Lozes,E.; Gilles,B.; Drowart,A.; Palfliet,K.; Fabienne Jurion; Roland,I.; Art,M.; Dufaux,M.; Nyabenda,J.Trefwoorden
Samenvatting:
TH1 cytokine secretion was examined in response to synthetic peptides of the 85A component of the major secreted, fibronectin-binding antigen 85 complex from Mycobacterium tuberculosis in seven different mouse strains infected with live M. bovis BCG. Twenty-eight overlapping 20-mer peptides covering the complete mature 295-amino-acid (AA) protein were synthesized. Significant interleukin-2 (IL-2) and gamma interferon (IFN-gamma) secretion could be measured following in vitro stimulation of spleen cells with these peptides. H-2d haplotype mice reacted preferentially against the amino-termina…