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Zoekresultaten - 8 results
Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials.
a follow-up study of the four randomised trials to investigate these outcomes. METHODS: 176,464 women aged 20-64 years were randomly assigned to HPV-based (experimental arm) or cytology-based (control arm ...
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK651
lipogenesis–two crucial arms of cancer growth– AMPK also ensures viability by metabolic reprogramming in cancer cells. AMPK activation by two indirect AMPK agonists AICAR and metformin (now in over 50 clinical ...
Antitumoral activity of parvovirus-mediated IL-2 and MCP-3/CCL7 delivery into human pancreatic cancer: implication of leucocyte recruitment
novel therapeutic strategies are being pursued to combat PDAC, including oncolytic viruses, either in their natural forms or armed with immunostimulatory molecules. Natural killer cells are critical ...
Causes and relevance of unsatisfactory and satisfactory but limited smears of liquid-based compared with conventional cervical cytology
nonsignificant increase with LBC. The detection rates of abnormalities found during 18 months of follow-up of unsatisfactory test results did not differ significantly between the 2 study arms, nor did they differ ...
How to evaluate emerging technologies in cervical cancer screening?
of cancer (or its surrogate, severe dysplasia) in the experimental arm at subsequent screening rounds. The 5-phases framework should guide researchers and test developers in planning assessment of new ...
International agreement to join forces in synthesizing evidence on new methods for cervical cancer prevention.
controlled trials, comparing cytology with HPV-based cervical cancer screening, consistently show increased detection of high-grade cervical intraepithelial neoplasia (CIN) in the HPV-arm. These results are in ...
Prime-boost strategies combining DNA and inactivated vaccines confer high immunity and protection in cattle against bovine herpesvirus-1.
cellular arms of the immune response primed with Bovine herpesvirus-1 (BoHV-1) DNA vaccines encoding glycoprotein D (gD) or gC+gD. Calves vaccinated according to the DNA prime-inactivated boost also showed ...
Crystal structure of a dimeric oxidized form of human peroxiredoxin 5.
including the alpha6 helix is completely reorganized and is isolated from the rest of the protein on an extended arm. In the oxidized dimer, the arm belonging to the first monomer now appears at the surface ...