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  3. Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.

Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.

Last updated on 22-8-2019 by Anonymous (not verified)

Public Access

Published

Peer reviewed scientific article

DOI : http://dx.doi.org/10.1016/j.neuropharm.2012.02.003

Authors

Bosier,B.; Muccioli,G.G.; Birgit Mertens; Sarre,S.; Michotte,Y.; Didier M. Lambert; Hermans,E.

Keywords

  1. access
  2. Activity
  3. Adult
  4. Agonist-selective coupling
  5. an
  6. analysi
  7. analysis
  8. AS
  9. brain
  10. cause
  11. CB1 cannabinoid receptor
  12. Control
  13. data
  14. Dopamine
  15. DRUG
  16. effect
  17. effects
  18. evidence
  19. exposure
  20. expression
  21. Functional
  22. G protein
  23. GPCR
  24. Increase
  25. IS
  26. metabolism
  27. metabolites
  28. ON
  29. rats
  30. Reduction
  31. regulation
  32. report
  33. response
  34. structure
  35. System
  36. Transmission
  37. trend
  38. Tyrosine hydroxylase

Abstract:

It is generally assumed that cannabinoids induce transient modulations of dopamine transmission through indirect regulation of its release. However, we previously described a direct cannabinoid-mediated control of tyrosine hydroxylase (TH) expression,
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