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Discovery and Development of an Advanced Lead for the Treatment of African Trypanosomiasis.
identified following screening against the most relevant trypanosome species. Selected hit compounds were extensively tested for metabolic stability, potency in mouse models for the various species, ...
Chemical Characterization of Feminine Intimate Products an Extractables & Leachables Investigation
migration studies using simulants of vaginal and menstrual fluids, followed by targeted quantification of the prioritized leachable chemicals. This strategy is applied to 64 FIP s, including absorbent hygiene ...
Characterization of functional nanoparticles applied in face masks by STEM-EDX
TEM specimens from the pieces of mask followed the methodology described in Wouters et al.[4] Ultra-thin sections of the textiles were prepared by embedding them in epoxy resin, followed by ultra-thin ...
First European pollen reanalysis for allergenic trees
source modules. The pollen season onset and its following propagation were reproduced based on the model internal formulations only. The corrections to the mean pollen productivity were introduced by ...
Towards a more effective REACH legislation in protecting human health.
data generated using modern science and technology. There is a need for improved assessment process not only before but also after entering the market. Objectivity, transparency, and the follow-up after ...
A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring
function from outside the EU, the population attributable fraction decreased from an average of 18 to 7%. To ensure more robust disease burden estimates and adequate follow-up of policy measures, more HBM ...
EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects
indications for genotoxicity were obtained. Finally, no formation of smaller particles following colonic fermentation of NC was observed. For the integration of these results in regulatory hazard assessment of ...
Development of strain-level shotgun metagenomics approaches to detect and characterize microbiological contaminants in the context of food safety
retrieved when two strains of the same species were present. The same protocol was then followed to investigate a real Salmonella foodborne outbreak. Two food samples were investigated and the Salmonella ...
Simultaneous Detection and Quantification of Aflatoxin M1, Eight Microcystin Congeners and Nodularin in Dairy Milk by LC-MS/MS
extracted with methanol 80%, followed by an SPE clean-up step before LC- MS / MS analysis. The LOQ was fixed at 1 µg/L for the nine cyanotoxins and 0.05 µg/L for AFM1. Recoveries were measured between 82.67% ...
Variability in the association between long-term exposure to ambient air pollution and mortality by exposure assessment method and covariate adjustment: A census-based country-wide cohort study
≥30 (mean follow-up: 9.97 years). Annual mean concentrations for fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone (O3) were assessed at baseline residential address ...