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Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers
first identified through RNA sequencing experiments conducted on two drug-exposed, susceptible strains for four antitubercular drugs. Based on these findings, we designed drug-specific multiplex ...
Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4-5 December 2014).
issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. In an effort to shift the ...
Survey on the Use of Whole-Genome Sequencing for Infectious Diseases Surveillance: Rapid Expansion of European National Capacities, 2015-2016.
epidemiology of infectious diseases and antimicrobial drug resistance. It provides precise geographical delineation of spread and enables incidence monitoring of pathogens at genotype level. Coupled with ...
The Monte Carlo validation framework for the discriminant partial least squares model extended with variable selection methods applied to authenticity studies of Viagra® based on chromatographic impurity profiles.
Counterfeit Drugs Discriminant Analysis Least-Squares Analysis Monte Carlo Method Sildenafil Citrate Abstract: The aim of this work was to develop a general framework for the validation of discriminant models ...
2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis.
Norbert Source: Eur J Med Chem, Volume 77, p.409-21 (2014) Keywords: Animals Antitubercular Agents Cell Line Dose-Response Relationship, Drug Isoquinolines Macrophages mice Microbial Sensitivity Tests ...
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
Agents Cell Line Cysteine Endopeptidases Drug Evaluation, Preclinical Genes, Reporter Humans Luciferases, Firefly Picornaviridae Protease Inhibitors Viral Proteins Abstract: Proteolytical cleavage of the ...
Implementing strategic bundles for infection prevention and management.
Angelis, G; Schumacher, M; Wolkewitz, M; Kleissle, E-M; Frank, U Source: Infection, Volume 40, Issue 2, p.225-8 (2012) Keywords: Anti-Bacterial Agents Cross Infection Disease Notification Drug Resistance, ...
A Simultaneous D-Optimal Designed Study for Population Pharmacokinetic Analyses of Mycophenolic Acid and Tacrolimus Early After Renal Transplantation86
Source: J.Clin.Pharmacol. (2011) Keywords: 0 a accuracy acid acute Adult Agent Agents Analyses approach approaches article AS at Combination corticosteroids Covariate Demographic Design DRUG drugs ...
Synthetic EthR inhibitors boost antituberculous activity of ethionamide36849
& inhibitors Antitubercular Agents article AS Binding Sites chemistry concept conventional culture de DNA-Binding Proteins DRUG Drug Resistance Drug Synergism drug therapy drugs effect effects ...
Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif L-Lys-D-Ala-D-Ala for use in a vancomycin biosensor93
Design detection Drug Design Drug Evaluation,Preclinical ET EVALUATION im IS journal Molecular MS ON Peptidoglycan Print Receptor receptors Research Research Support SB- IM Spectrophotometry,Ultraviolet ...