Causes and modes of transmission

What causes hepatitis?

Hepatitis can be caused by:

  • Viruses (HAVHBVHCVHDVHEV and other viruses)
  • Substances that are toxic to the liver (alcohol, medicines, chemical products etc.) 
  • some auto-immune diseases.

How are the various hepatitis viruses transmitted?

Hepatitis A  

Mainly via the faecal-oral route (direct of indirect contact with infected faeces):

  • consumption of food or contaminated water
  • during sexual relations with oral-anal contact (STI).

Hepatitis A and E are much more common in countries with poor hygiene conditions. 

Hepatitis B  

Mainly through percutaneous/mucosal contact with infected blood or bodily fluids (sperm, saliva, etc.):

  • During sexual relations without a condom with an infected person (STI)
  • through infected blood (a needle prick, sharing drug-related injection equipment etc.) 
  • from mother to child.

Hepatitis C 

Mainly percuataneous/mucosal contact with blood/blood products:

  • via infected blood (sharing drug-related injection equipment, a blood transfusion or organ transplant prior to 1990, medical injections with infected equipment, a needle prick, a tattoo or piercing with unsterilised equipment, etc.) 
  • During sexual relations without a condom (STI), with exposure to blood (traumatic sexual relations, wounds etc.)
  • from mother to child.

Hepatitis D

  • Only people who are infected with HBV can contract hepatitis D. Co-infection with HDV and HBV simultaneously can aggravate the evolution of hepatitis B. Vaccines against hepatitis B also indirectly protect against an HDV infection.
  • Transmission occurs through exposure to infected blood, blood products or other bodily fluids.

Hepatitis E

  • The consumption of food or contaminated water (for genotype 1 often infection via faeces in endemic countries; for genotype 3 often infection via processing raw pork products in food).
  • Via infected blood on rare occasions (transfusion of infected blood products).

In collaboration with the Cliniques universitaires Saint-Luc, Sciensano houses the National reference centre for hepatitis A, B, C, D and E, which analyses strains of the hepatitis virus. Sciensano also performs epidemiological surveillance on viral forms of hepatitis in Belgium and controls the quality of the vaccines.

In the media

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